Bone Coverage Around Hydroxyapatite/Poly(-Lactide) Composite Is Determined According to Depth from Cortical Bone Surface in Rabbits

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2021 Apr 3

PMID 33802655

Citations 1

Authors

Kazuaki Morizane

Koji Goto

Toshiyuki Kawai

Shunsuke Fujibayashi

Bungo Otsuki

Takayoshi Shimizu

Shuichi Matsuda

Affiliations

Soon will be listed here.

Abstract

Composites of unsintered hydroxyapatite (HA) and poly(-lactide) (PLLA) reinforced by compression forging are biodegradable, bioactive, and have ultrahigh strength. However, foreign body reactions to PLLA and physical irritation can occur when not covered by bone. We aimed to confirm the relationships between the depth of the implanted HA-PLLA threaded pins and the new bone formation. We inserted HA-PLLA composite threaded pins (diameter: 2.0 or 4.5 mm) into the femoral and tibial bones of 32 mature male Japanese white rabbits (weight 3.0-3.5 kg) with the pin head 1 or 0 mm below or protruding 1 or 2 mm above surrounding cortical bone. Eight euthanized rabbits were radiologically and histologically assessed at various intervals after implantation. Bone bridging was complete over pins of both diameters at ~12 weeks, when inserted 1 mm below the surface, but the coverage of the pins inserted at 0 mm varied. Bone was not formed when the pins protruded >1 mm from the bone surface. No inflammation developed around the pins by 25 weeks. However, foreign body reactions might develop if composites are fixed above the bone surface, and intraosseous fixation would be desirable using double-threaded screws or a countersink to avoid screw head protrusion.

Citing Articles

The Potential for Foreign Body Reaction of Implanted Poly-L-Lactic Acid: A Systematic Review.

Nonhoff M, Puetzler J, Hasselmann J, Fobker M, Gosheger G, Schulze M Polymers (Basel). 2024; 16(6).

PMID: 38543422 PMC: 10974195. DOI: 10.3390/polym16060817.

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