Autophagy and Extracellular Vesicles in Colorectal Cancer: Interactions and Common Actors?

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Apr 3

PMID 33801266

Citations 9

Authors

Clement Auger

Niki Christou

Aude Brunel

Aurelie Perraud

Mireille Verdier

Affiliations

Soon will be listed here.

Abstract

Autophagy is a homeostatic process involved in the degradation of disabled proteins and organelles using lysosomes. This mechanism requires the recruitment of specialized proteins for vesicle trafficking, that may also be involved in other types of machinery such as the biogenesis and secretion of extracellular vesicles (EVs), and particularly small EVs called exosomes. Among these proteins, Rab-GTPases may operate in both pathways, thus representing an interesting avenue for further study regarding the interaction between autophagy and extracellular vesicle machinery. Both mechanisms are involved in the development of colorectal cancer (CRC), particularly in cancer stem cell (CSC) survival and communication, although they are not specific to CRC or CSCs. This highlights the importance of studying the crosstalk between autophagy and EVs biogenesis and release.

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References

Yang X, Xu X, Zhu J, Zhang S, Wu Y, Wu Y . miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts. Oncotarget. 2016; 7(48):79617-79628. PMC: 5346740. DOI: 10.18632/oncotarget.12873. View

Mulcahy Levy J, Towers C, Thorburn A . Targeting autophagy in cancer. Nat Rev Cancer. 2017; 17(9):528-542. PMC: 5975367. DOI: 10.1038/nrc.2017.53. View

Hurley J . ESCRTs are everywhere. EMBO J. 2015; 34(19):2398-407. PMC: 4601661. DOI: 10.15252/embj.201592484. View

Bader C, Shandala T, Ng Y, Johnson I, Brooks D . Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes. Biol Open. 2015; 4(11):1345-55. PMC: 4728360. DOI: 10.1242/bio.013979. View

Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008; 10(12):1470-6. PMC: 3423894. DOI: 10.1038/ncb1800. View

Singh S, Vats S, Chia A, Tan T, Deng S, Ong M . Dual role of autophagy in hallmarks of cancer. Oncogene. 2017; 37(9):1142-1158. DOI: 10.1038/s41388-017-0046-6. View

Levine B, Kroemer G . Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 2019; 176(1-2):11-42. PMC: 6347410. DOI: 10.1016/j.cell.2018.09.048. View

Adnan M, Islam W, Zhang J, Zheng W, Lu G . Diverse Role of SNARE Protein Sec22 in Vesicle Trafficking, Membrane Fusion, and Autophagy. Cells. 2019; 8(4). PMC: 6523435. DOI: 10.3390/cells8040337. View

Henne W, Stenmark H, Emr S . Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol. 2013; 5(9). PMC: 3753708. DOI: 10.1101/cshperspect.a016766. View

10.

Henne W, Buchkovich N, Emr S . The ESCRT pathway. Dev Cell. 2011; 21(1):77-91. DOI: 10.1016/j.devcel.2011.05.015. View

11.

Sasaki K, Tsuno N, Sunami E, Tsurita G, Kawai K, Okaji Y . Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer. 2010; 10:370. PMC: 2914703. DOI: 10.1186/1471-2407-10-370. View

12.

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

13.

Liu J, Zhang Y, Liu A, Wang J, Li L, Chen X . Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells. Int J Mol Sci. 2016; 17(4):531. PMC: 4848987. DOI: 10.3390/ijms17040531. View

14.

Lindoso R, Collino F, Vieyra A . Extracellular vesicles as regulators of tumor fate: crosstalk among cancer stem cells, tumor cells and mesenchymal stem cells. Stem Cell Investig. 2017; 4:75. PMC: 5639036. DOI: 10.21037/sci.2017.08.08. View

15.

Galluzzi L, Pietrocola F, Bravo-San Pedro J, Amaravadi R, Baehrecke E, Cecconi F . Autophagy in malignant transformation and cancer progression. EMBO J. 2015; 34(7):856-80. PMC: 4388596. DOI: 10.15252/embj.201490784. View

16.

Thery C . Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep. 2011; 3:15. PMC: 3155154. DOI: 10.3410/B3-15. View

17.

Kroemer G, Marino G, Levine B . Autophagy and the integrated stress response. Mol Cell. 2010; 40(2):280-93. PMC: 3127250. DOI: 10.1016/j.molcel.2010.09.023. View

18.

Savina A, Fader C, Damiani M, Colombo M . Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic. 2005; 6(2):131-43. DOI: 10.1111/j.1600-0854.2004.00257.x. View

19.

Li J, Yang B, Zhou Q, Wu Y, Shang D, Guo Y . Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. Carcinogenesis. 2013; 34(6):1343-51. DOI: 10.1093/carcin/bgt063. View

20.

Migneault F, Hebert M . Autophagy, tissue repair, and fibrosis: a delicate balance. Matrix Biol. 2021; 100-101:182-196. DOI: 10.1016/j.matbio.2021.01.003. View