Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Apr 3

PMID 33800702

Citations 9

Authors

Nansi Lopez-Valverde

Bruno Macedo-de-Sousa

Antonio Lopez-Valverde

Juan Manuel Ramirez

Affiliations

Soon will be listed here.

Abstract

Titanium (Ti) dental implant failure as a result of infection has been established at 40%, being regarded as one of the most habitual and untreatable problems. Current research is focused on the design of new surfaces that can generate long-lasting, infection-free osseointegration. The purpose of our study was to assess studies on Ti implants coated with different antibacterial surfaces, assessing their osseointegration. The PubMed, Web of Science and Scopus databases were electronically searched for in vivo studies up to December 2020, selecting six studies that met the inclusion criteria. The quality of the selected studies was assessed using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) criteria and Systematic Review Center for Laboratory animal Experimentation's (SYRCLE's) risk of bias tool. Although all the included studies, proved greater osseointegration capacity of the different antibacterial surfaces studied, the methodological quality and experimental models used in some of them make it difficult to draw predictable conclusions. Because of the foregoing, we recommend caution when interpreting the results obtained.

Citing Articles

Biomimetic Coatings in Implant Dentistry: A Quick Update.

Abdulghafor M, Mahmood M, Tassery H, Tardivo D, Falguiere A, Lan R J Funct Biomater. 2024; 15(1).

PMID: 38248682 PMC: 10816551. DOI: 10.3390/jfb15010015.

Surface Coatings of Dental Implants: A Review.

Inchingolo A, Malcangi G, Ferrante L, Del Vecchio G, Viapiano F, Inchingolo A J Funct Biomater. 2023; 14(5).

PMID: 37233397 PMC: 10218820. DOI: 10.3390/jfb14050287.

Prediction of Bone Healing around Dental Implants in Various Boundary Conditions by Deep Learning Network.

Kung P, Hsu C, Yang A, Chen N, Tsou N Int J Mol Sci. 2023; 24(3).

PMID: 36768272 PMC: 9915893. DOI: 10.3390/ijms24031948.

Correction of large jawbone defect in the mouse using immature osteoblast-like cells and a 3D polylactic acid scaffold.

Suzuki S, Venkataiah V, Yahata Y, Kitagawa A, Inagaki M, Njuguna M PNAS Nexus. 2023; 1(4):pgac151.

PMID: 36714858 PMC: 9802318. DOI: 10.1093/pnasnexus/pgac151.

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants.

Kim S, Choi A, Park J, Jang Y, Lee M Polymers (Basel). 2022; 14(23).

PMID: 36501711 PMC: 9737906. DOI: 10.3390/polym14235317.

References

Zhao L, Chu P, Zhang Y, Wu Z . Antibacterial coatings on titanium implants. J Biomed Mater Res B Appl Biomater. 2009; 91(1):470-80. DOI: 10.1002/jbm.b.31463. View

Javed F, Ahmed H, Crespi R, Romanos G . Role of primary stability for successful osseointegration of dental implants: Factors of influence and evaluation. Interv Med Appl Sci. 2014; 5(4):162-7. PMC: 3873594. DOI: 10.1556/IMAS.5.2013.4.3. View

Kim S, Song S, Yun Y, Choi B, Kwon I, Bae M . The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function. Biomaterials. 2010; 32(2):366-73. DOI: 10.1016/j.biomaterials.2010.09.008. View

Zhou J, Wang X, Zhao L . Antibacterial, angiogenic, and osteogenic activities of Ca, P, Co, F, and Sr compound doped titania coatings with different Sr content. Sci Rep. 2019; 9(1):14203. PMC: 6775141. DOI: 10.1038/s41598-019-50496-3. View

Shoulders H, Garner K, Singla D . Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis. Transl Res. 2018; 203:1-14. PMC: 6314201. DOI: 10.1016/j.trsl.2018.07.006. View

Hall J, Sorensen R, Wozney J, Wikesjo U . Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model. J Clin Periodontol. 2007; 34(5):444-51. DOI: 10.1111/j.1600-051X.2007.01064.x. View

Rocher C, Singla D . SMAD-PI3K-Akt-mTOR pathway mediates BMP-7 polarization of monocytes into M2 macrophages. PLoS One. 2013; 8(12):e84009. PMC: 3869858. DOI: 10.1371/journal.pone.0084009. View

Becker W, Becker B, Ricci A, Bahat O, Rosenberg E, Rose L . A prospective multicenter clinical trial comparing one- and two-stage titanium screw-shaped fixtures with one-stage plasma-sprayed solid-screw fixtures. Clin Implant Dent Relat Res. 2001; 2(3):159-65. DOI: 10.1111/j.1708-8208.2000.tb00007.x. View

Hotchkiss K, Sowers K, Olivares-Navarrete R . Novel in vitro comparative model of osteogenic and inflammatory cell response to dental implants. Dent Mater. 2018; 35(1):176-184. DOI: 10.1016/j.dental.2018.11.011. View

10.

Gristina A . Biomaterial-centered infection: microbial adhesion versus tissue integration. Science. 1987; 237(4822):1588-95. DOI: 10.1126/science.3629258. View

11.

Shimabukuro M . Antibacterial Property and Biocompatibility of Silver, Copper, and Zinc in Titanium Dioxide Layers Incorporated by One-Step Micro-Arc Oxidation: A Review. Antibiotics (Basel). 2020; 9(10). PMC: 7589568. DOI: 10.3390/antibiotics9100716. View

12.

Hartjen P, Hoffmann A, Henningsen A, Barbeck M, Kopp A, Kluwe L . Plasma Electrolytic Oxidation of Titanium Implant Surfaces: Microgroove-Structures Improve Cellular Adhesion and Viability. In Vivo. 2018; 32(2):241-247. PMC: 5905190. DOI: 10.21873/invivo.11230. View

13.

Saulacic N, Schaller B . Prevalence of Peri-Implantitis in Implants with Turned and Rough Surfaces: a Systematic Review. J Oral Maxillofac Res. 2019; 10(1):e1. PMC: 6498817. DOI: 10.5037/jomr.2019.10101. View

14.

Ding L, Zhang P, Wang X, Kasugai S . A doxycycline-treated hydroxyapatite implant surface attenuates the progression of peri-implantitis: A radiographic and histological study in mice. Clin Implant Dent Relat Res. 2018; 21(1):154-159. DOI: 10.1111/cid.12695. View

15.

Wall I, Donos N, Carlqvist K, Jones F, Brett P . Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone. 2009; 45(1):17-26. DOI: 10.1016/j.bone.2009.03.662. View

16.

Le Guehennec L, Soueidan A, Layrolle P, Amouriq Y . Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater. 2006; 23(7):844-54. DOI: 10.1016/j.dental.2006.06.025. View

17.

Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M, Geis-Gerstorfer J . Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res A. 2005; 76(2):323-34. DOI: 10.1002/jbm.a.30518. View

18.

Buser D, Janner S, Wittneben J, Bragger U, Ramseier C, Salvi G . 10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients. Clin Implant Dent Relat Res. 2012; 14(6):839-51. DOI: 10.1111/j.1708-8208.2012.00456.x. View

19.

Ding L, Zhang P, Wang X, Hao J, Aoki K, Kuroda S . Effect of doxycycline-treated hydroxyapatite surface on bone apposition: A histomophometric study in murine maxillae. Dent Mater J. 2017; 37(1):130-138. DOI: 10.4012/dmj.2017-007. View

20.

Mouhyi J, Dohan Ehrenfest D, Albrektsson T . The peri-implantitis: implant surfaces, microstructure, and physicochemical aspects. Clin Implant Dent Relat Res. 2009; 14(2):170-83. DOI: 10.1111/j.1708-8208.2009.00244.x. View