Postbiotics, Metabolic Signaling, and Cancer

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Apr 3

PMID 33799580

Citations 14

Authors

Nikola Vrzackova

Tomas Ruml

Jaroslav Zelenka

Affiliations

Soon will be listed here.

Abstract

Postbiotics are health-promoting microbial metabolites delivered as a functional food or a food supplement. They either directly influence signaling pathways of the body or indirectly manipulate metabolism and the composition of intestinal microflora. Cancer is the second leading cause of death worldwide and even though the prognosis of patients is improving, it is still poor in the substantial part of the cases. The preventable nature of cancer and the importance of a complex multi-level approach in anticancer therapy motivate the search for novel avenues of establishing the anticancer environment in the human body. This review summarizes the principal findings demonstrating the usefulness of both natural and synthetic sources of postbotics in the prevention and therapy of cancer. Specifically, the effects of crude cell-free supernatants, the short-chain fatty acid butyrate, lactic acid, hydrogen sulfide, and β-glucans are described. Contradictory roles of postbiotics in healthy and tumor tissues are highlighted. In conclusion, the application of postbiotics is an efficient complementary strategy to combat cancer.

Citing Articles

Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases.

Kapoor S, Gupta M, Sapra L, Kaur T, Srivastava R Bone Rep. 2024; 23:101809.

PMID: 39497943 PMC: 11532283. DOI: 10.1016/j.bonr.2024.101809.

Appraisal of postbiotics in cancer therapy.

Sudaarsan A, Ghosh A Front Pharmacol. 2024; 15:1436021.

PMID: 39372197 PMC: 11449718. DOI: 10.3389/fphar.2024.1436021.

Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Nissle 1917 strain.

Falzone L, Lavoro A, Candido S, Salmeri M, Zanghi A, Libra M Gut Microbes. 2024; 16(1):2397874.

PMID: 39229962 PMC: 11376418. DOI: 10.1080/19490976.2024.2397874.

Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds.

Leung H, Lo E, Zhang F, Felicianna , Ismaiah M, Chen C Int J Mol Sci. 2024; 25(12).

PMID: 38928054 PMC: 11203446. DOI: 10.3390/ijms25126348.

Initiation of Apoptotic Pathway by the Cell-Free Supernatant Synthesized from Weissella cibaria Through In-Silico and In-Vitro Methods.

Manoharan M, Ragothaman P, Balasubramanian T Appl Biochem Biotechnol. 2023; 196(7):4700-4724.

PMID: 37751008 DOI: 10.1007/s12010-023-04688-3.

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