An Overview on the Development of MRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo

Overview

Journal Vaccines (Basel)

Date 2021 Apr 3

PMID 33799516

Citations 13

Authors

Md Motiar Rahman

Nan Zhou

Jiandong Huang

Affiliations

Soon will be listed here.

Abstract

The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to its ability for prompt development, high potency, and potential for secure administration and low-cost production. Nonetheless, the application has still been limited by the instability as well as the ineffective delivery of mRNA in vivo. Current technological improvements have now mostly overcome these concerns, and manifold mRNA vaccine plans against various forms of malignancies and infectious ailments have reported inspiring outcomes in both humans and animal models. This article summarizes recent mRNA-based vaccine developments, advances of in vivo mRNA deliveries, reflects challenges and safety concerns, and future perspectives, in developing the mRNA vaccine platform for extensive therapeutic use.

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