High-fat Diet Activates a PPAR-δ Program to Enhance Intestinal Stem Cell Function

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Apr 2

PMID 33798420

Citations 6

Authors

Semir Beyaz

Miyeko D Mana

Omer H Yilmaz

Affiliations

Soon will be listed here.

Citing Articles

Building better barriers: how nutrition and undernutrition impact pediatric intestinal health.

Andres S, Zhang Y, Kuhn M, Scottoline B Front Immunol. 2023; 14:1192936.

PMID: 37545496 PMC: 10401430. DOI: 10.3389/fimmu.2023.1192936.

Modulation of stem cell fate in intestinal homeostasis, injury and repair.

Wang Z, Qu Y, Cui M World J Stem Cells. 2023; 15(5):354-368.

PMID: 37342221 PMC: 10277971. DOI: 10.4252/wjsc.v15.i5.354.

Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.

Cable J, Rathmell J, Pearce E, Ho P, Haigis M, Mamedov M Ann N Y Acad Sci. 2023; 1523(1):38-50.

PMID: 36960914 PMC: 10367315. DOI: 10.1111/nyas.14976.

A dietary change to a high-fat diet initiates a rapid adaptation of the intestine.

Enriquez J, McCauley H, Zhang K, Sanchez J, Kalin G, Lang R Cell Rep. 2022; 41(7):111641.

PMID: 36384107 DOI: 10.1016/j.celrep.2022.111641.

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.

Beyaz S, Chung C, Mou H, Bauer-Rowe K, Xifaras M, Ergin I Cell Stem Cell. 2021; 28(11):1922-1935.e5.

PMID: 34529935 PMC: 8650761. DOI: 10.1016/j.stem.2021.08.007.

References

Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S . High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016; 531(7592):53-8. PMC: 4846772. DOI: 10.1038/nature17173. View

Li W, Houston M, Peregrina K, Ye K, Augenlicht L . Effects of Diet Choice on Stem Cell Function Necessitate Clarity in Selection and Reporting. Cell Stem Cell. 2020; 27(1):11-12. PMC: 8140399. DOI: 10.1016/j.stem.2020.06.014. View

Beyaz S, Yilmaz O . Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ Pathway. Clin Cancer Res. 2016; 22(23):5636-5641. PMC: 5135602. DOI: 10.1158/1078-0432.CCR-16-0775. View

Softic S, Meyer J, Wang G, Gupta M, Batista T, Lauritzen H . Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metab. 2019; 30(4):735-753.e4. PMC: 7816129. DOI: 10.1016/j.cmet.2019.09.003. View

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