Variability Measurements Provide Additional Value to Shear Wave Elastography in the Diagnosis of Pancreatic Cancer

Overview

Journal Sci Rep

Specialty Science

Date 2021 Apr 2

PMID 33795822

Citations 6

Authors

Masakatsu Yoshikawa

Takuya Ishikawa

Eizaburo Ohno

Tadashi Iida

Kazuhiro Furukawa

Masanao Nakamura

Takashi Honda

Masatoshi Ishigami

Fumie Kinoshita

Hiroki Kawashima

Mitsuhiro Fujishiro

Affiliations

Soon will be listed here.

Abstract

Shear wave elastography (SWE) is a technique to non-invasively and quantitatively evaluate tissue stiffness. We aimed to investigate whether we can differentiate pancreatic cancer (PC) from normal pancreatic parenchyma (NPP) by SWE using transabdominal ultrasound. We investigated a total of 106 patients (84 with NPP and 22 with PC) whose pancreatic elastic modulus was measured by two-dimensional SWE (2D-SWE). Intra-rater reliability in this study was examined, and three measurements were sufficiently reliable. There were no differences between the two groups in factors that could affect SWE measurements. The median value of the elastic modulus was 5.70 kPa in the PC patients and 5.66 kPa in the NPP group, which was not significantly different (P = 0.785). On the contrary, the range was 8.64 kPa and 4.72 kPa, with a significantly greater range in the PC patients (P = 0.001). In conclusion, the median elastic modulus measured by 2D-SWE was not significantly different between PC and NPP, and evaluating the obtained elastic modulus itself is not useful in differentiation. However, the variability was significantly greater in PC than in NPP. Evaluating the range of elasticities will provide additional information in SWE, which may be useful in the diagnosis of PC.

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