Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but Not Serotonin in Central Pattern Generator Swim Interneurons

Overview

Journal Integr Org Biol

Publisher Oxford University Press

Specialty Biology

Date 2021 Apr 1

PMID 33791588

Citations 2

Authors

Thomas J Pirtle

Richard A Satterlie

Affiliations

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Abstract

Both nitric oxide (NO) and serotonin (5HT) mediate swim acceleration in the marine mollusk, . In this study, we examine the role that the second messenger, cyclic guanosine monophosphate (cGMP), plays in mediating NO and 5HT-induced swim acceleration. We observed that the application of an analog of cGMP or an activator of soluble guanylyl cyclase (sGC) increased fictive locomotor speed recorded from Pd-7 interneurons of the animal's locomotor central pattern generator. Moreover, inhibition of sGC decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in . Because NO has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in swim interneurons that are consistent with cellular changes produced by 5HT application, we hypothesize that both NO and 5HT function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates NO-induced but not 5HT-induced swim acceleration in .

Citing Articles

Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates.

Locascio A, Annona G, Caccavale F, DAniello S, Agnisola C, Palumbo A Int J Mol Sci. 2023; 24(13).

PMID: 37446358 PMC: 10342570. DOI: 10.3390/ijms241311182.

A review of the circuit-level and cellular mechanisms contributing to locomotor acceleration in the marine mollusk .

Pirtle T Front Neurosci. 2023; 16:1072974.

PMID: 36620465 PMC: 9815461. DOI: 10.3389/fnins.2022.1072974.

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