Evaluation of Phytochemicals and Bioactive Properties in Mangrove Associate . Ex J.F.Gmel. of Indian Sundarbans

Overview

Journal Front Pharmacol

Date 2021 Apr 1

PMID 33790782

Citations 7

Authors

Madhumita Roy

Tapan K Dutta

Affiliations

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Abstract

Suaeda monoica Forssk. ex J.F.Gmel. (Amaranthaceae), a mangrove associate and ethno-medicinal herb of Indian Sundarbans, was investigated as a promising source of bioactive compounds. Various polar and nonpolar solvent extracts of the leaf and root-shoot parts of the plant exhibited antioxidant, antibacterial, antifungal, allelopathic, mosquitocidal, antihaemolytic and antidiuretic potential. Moreover, to meet pharmacological requirements, the antioxidant ability of the plant was validated by both chemical and biological analyses. Extraction yield and presence of different phytochemicals like phenolics, flavonoids, tannins and saponins were compared in various solvent-extracted fractions. Principle component analysis revealed that the antioxidant property present in different extracts maintained a positive correlation with the occurrence of polyphenols (phenolics, tannins and flavonoids). Biochemical evaluation, HPLC examination and GC-MS analysis showed a differential level of the presence of various phytochemicals in different solvent extracts. In contrast to mosquitocidal, antioxidant, antihaemolytic and phytotoxic properties which were observed to be dominant in polar solvent extracts, maximum antibacterial potency was detected in nonpolar -hexane fractions. Overall, the plant extract is nontoxic in nature and a dose amounting to 3,000 mg/kg was well tolerated by Swiss albino mice. A combination of HPLC and GC-MS analyses showed the presence of a large number of structurally diverse phytochemicals, many of which had already been reported as insecticidal, mosquitocidal, antibacterial, herbicidal, antidiuretic, antioxidant and anti-haemolytic compounds. All these findings support that the least explored traditional edible medicinal mangrove associate S.monoica is enriched with multiple bioactive molecules and may be considered as one of the richest sources of various lead molecules of pharmaceutical importance.

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References

Chotsaeng N, Laosinwattana C, Charoenying P . Inhibitory Effects of a Variety of Aldehydes on Amaranthus tricolor L. and Echinochloa crus-galli (L.) Beauv. Molecules. 2018; 23(2). PMC: 6016959. DOI: 10.3390/molecules23020471. View

Sivakumar R, Jebanesan A, Govindarajan M, Rajasekar P . Larvicidal and repellent activity of tetradecanoic acid against Aedes aegypti (Linn.) and Culex quinquefasciatus (Say.) (Diptera:Culicidae). Asian Pac J Trop Med. 2011; 4(9):706-10. DOI: 10.1016/S1995-7645(11)60178-8. View

Sakamoto A, Murata N . The role of glycine betaine in the protection of plants from stress: clues from transgenic plants. Plant Cell Environ. 2002; 25(2):163-171. DOI: 10.1046/j.0016-8025.2001.00790.x. View

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M . Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10):1231-7. DOI: 10.1016/s0891-5849(98)00315-3. View

Sahebi M, Hanafi M, Siti Nor Akmar A, Rafii M, Azizi P, Tengoua F . Importance of silicon and mechanisms of biosilica formation in plants. Biomed Res Int. 2015; 2015:396010. PMC: 4317640. DOI: 10.1155/2015/396010. View

Lee Y, Kang M, Cho S, Jeong C . Effects of constituents of Amomum xanthioides on gastritis in rats and on growth of gastric cancer cells. Arch Pharm Res. 2007; 30(4):436-43. DOI: 10.1007/BF02980217. View

Patra J, Dhal N, Thatoi H . In vitro bioactivity and phytochemical screening of Suaeda maritima (Dumort): a mangrove associate from Bhitarkanika, India. Asian Pac J Trop Med. 2011; 4(9):727-34. DOI: 10.1016/S1995-7645(11)60182-X. View

Ganeshpurkar A, Saluja A . The Pharmacological Potential of Rutin. Saudi Pharm J. 2017; 25(2):149-164. PMC: 5355559. DOI: 10.1016/j.jsps.2016.04.025. View

Burrows C, Muller J . Oxidative Nucleobase Modifications Leading to Strand Scission. Chem Rev. 2002; 98(3):1109-1152. DOI: 10.1021/cr960421s. View

10.

Lahlou S, Tahraoui A, Israili Z, Lyoussi B . Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol. 2006; 110(3):458-63. DOI: 10.1016/j.jep.2006.10.005. View

11.

Hopkins A, Mason J, Overington J . Can we rationally design promiscuous drugs?. Curr Opin Struct Biol. 2006; 16(1):127-36. DOI: 10.1016/j.sbi.2006.01.013. View

12.

Beauchamp C, Fridovich I . Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971; 44(1):276-87. DOI: 10.1016/0003-2697(71)90370-8. View

13.

Darabi H, Mohandessi S, Balavar Y, Aghapoor K . A structure-activity relationship study on a natural germination inhibitor, 2-methoxy-4-vinylphenol (MVP), in wheat seeds to evaluate its mode of action. Z Naturforsch C J Biosci. 2007; 62(9-10):694-700. DOI: 10.1515/znc-2007-9-1012. View

14.

Zhou C, Min J, Liu Z, Young A, Deshazer H, Gao T . Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Bioorg Med Chem Lett. 2008; 18(4):1308-11. DOI: 10.1016/j.bmcl.2008.01.031. View

15.

Ksouri R, Ksouri W, Jallali I, Debez A, Magne C, Hiroko I . Medicinal halophytes: potent source of health promoting biomolecules with medical, nutraceutical and food applications. Crit Rev Biotechnol. 2011; 32(4):289-326. DOI: 10.3109/07388551.2011.630647. View

16.

Hailu W, Engidawork E . Evaluation of the diuretic activity of the aqueous and 80% methanol extracts of Ajuga remota Benth (Lamiaceae) leaves in mice. BMC Complement Altern Med. 2014; 14:135. PMC: 3997187. DOI: 10.1186/1472-6882-14-135. View

17.

Carta G, Murru E, Banni S, Manca C . Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications. Front Physiol. 2017; 8:902. PMC: 5682332. DOI: 10.3389/fphys.2017.00902. View

18.

Srinivasan M, Sudheer A, Menon V . Ferulic Acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr. 2008; 40(2):92-100. PMC: 2127228. DOI: 10.3164/jcbn.40.92. View

19.

Pelkonen O, Xu Q, Fan T . Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?. J Tradit Complement Med. 2014; 4(1):1-7. PMC: 4032837. DOI: 10.4103/2225-4110.124323. View

20.

Aparna V, Dileep K, Mandal P, Karthe P, Sadasivan C, Haridas M . Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment. Chem Biol Drug Des. 2012; 80(3):434-9. DOI: 10.1111/j.1747-0285.2012.01418.x. View