The Eminent Role of MicroRNAs in the Pathogenesis of Alzheimer's Disease

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2021 Apr 1

PMID 33790780

Citations 27

Authors

Mohammad Samadian

Mahdi Gholipour

Mohammadreza Hajiesmaeili

Mohammad Taheri

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is an irrevocable neurodegenerative condition characterized by the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and neurofibrillary tangles mainly comprising extremely phosphorylated Tau proteins. Recent studies have emphasized the role of microRNAs (miRNAs) in the development of AD. A number of miRNAs, namely, miR-200a-3p, miR-195, miR-338-5p, miR-34a-5p, miR-125b-5p, miR-132, miR-384, miR-339-5p, miR-135b, miR-425-5p, and miR-339-5p, have been shown to participate in the development of AD through interacting with BACE1. Other miRNAs might affect the inflammatory responses in the course of AD. Aberrant expression of several miRNAs in the plasma samples of AD subjects has been shown to have the aptitude for differentiation of AD subjects from healthy subjects. Finally, a number of AD-modifying agents affect miRNA profile in cell cultures or animal models. We have performed a comprehensive search and summarized the obtained data about the function of miRNAs in AD in the current review article.

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