Association Between Serum Fibroblast Growth Factor 21 Level and Sight-threatening Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes

Overview

Journal BMJ Open Diabetes Res Care

Specialty Endocrinology

Date 2021 Apr 1

PMID 33789910

Citations 7

Authors

Shi Jin

Ning Xia

Lingling Han

Affiliations

Soon will be listed here.

Abstract

Introduction: We conducted this cross-sectional study to explore the relationship between serum fibroblast growth factor 21 (FGF21) level and sight-threatening diabetic retinopathy (STDR).

Research Design And Methods: A total of 654 patients with type 2 diabetes were recruited. Diabetic retinopathy (DR) was evaluated by the bilateral retinal photography, and patients were assigned into groups of no DR (NDR) (n=345, 52.75%), non-sight-threatening diabetic retinopathy (NSTDR) (n=207, 31.65%), involving patients with mild or moderate non-proliferative retinopathy (NPDR) and STDR (n=102, 15.60%), including those with severe NPDR or proliferative diabetic retinopathy (PDR). Serum FGF21 levels were quantified by a sandwich ELISA. Patients were divided into quartiles according to their serum FGF21 level.

Results: There was a significant difference in serum FGF21 level among the three groups of patients (p<0.01). Compared with other quartiles (Q1-Q3), the patients in Q4 had a higher prevalence of DR and STDR (p<0.05). Compared with Q1, a positive association was observed between serum FGF21 level and DR in Q3 and Q4 (p<0.01). After adjusting for age, gender and other risk factors, serum FGF21 level in Q4 was found to be associated with increased risk of DR and STDR (p<0.01). Serum FGF21 level was noted as an independent risk factor for DR and STDR (p<0.01). Serum FGF21 level >478.76 pg/mL suggested the occurrence of DR and that level >554.69 pg/mL indicated STDR (p<0.01).

Conclusions: Serum FGF21 level was a biomarker for the risk of developing DR or STDR. The risk of STDR increased when the serum FGF21 level of patients with type 2 diabetes was >554.69 pg/mL.

Citing Articles

The association between fibroblast growth factor 21 with diabetes retinopathy among type 2 diabetes mellitus patients: a systematic review, meta-analysis, and meta-regression.

Basir H, Nugrahani A, Aman A, Bakri S, Rasyid H, Umar H PeerJ. 2024; 12:e18308.

PMID: 39687000 PMC: 11648683. DOI: 10.7717/peerj.18308.

Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: a meta-analysis.

Jiang Y, Zhang W, Xu Y, Zeng X, Sun X Front Endocrinol (Lausanne). 2024; 15:1390035.

PMID: 39257905 PMC: 11384578. DOI: 10.3389/fendo.2024.1390035.

Circulating serum fibroblast growth factor 21 as risk and prognostic biomarker of retinal artery occlusion.

Shi R, Liu H, Xia K, Li Y, Chen T, Li X Sci Rep. 2024; 14(1):11854.

PMID: 38789571 PMC: 11126651. DOI: 10.1038/s41598-024-62588-w.

Assessment of fibroblast growth factor 21 in children with type 1 diabetes mellitus in relation to microvascular complications.

Tantawy N, Sherif E, Matter R, Salah N, Abozeid N, Atif H Pediatr Endocrinol Diabetes Metab. 2023; 29(2):64-74.

PMID: 37728457 PMC: 10411091. DOI: 10.5114/pedm.2022.121372.

The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China.

You L, Hong X, Wu H, Liang D, Li F, Zheng D BMC Endocr Disord. 2023; 23(1):188.

PMID: 37658393 PMC: 10472657. DOI: 10.1186/s12902-023-01426-y.

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