Dynamic Interplay Between Cell Membrane Tension and Clathrin-mediated Endocytosis

Overview

Journal Biol Cell

Specialty Cell Biology

Date 2021 Mar 31

PMID 33788963

Citations 28

Authors

Umidahan Djakbarova

Yasaman Madraki

Emily T Chan

Comert Kural

Affiliations

Soon will be listed here.

Abstract

Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on the membrane, can regulate a myriad of cellular functions, including membrane resealing, cell motility, polarisation, shape maintenance, membrane area control and endocytic vesicle trafficking. This review focuses on mechanoregulation of clathrin-mediated endocytosis (CME). We first delineate the origins of cell membrane tension and the factors that yield to its spatial and temporal fluctuations within cells. We then review the recent literature demonstrating that tension on the membrane is a fast-acting and reversible regulator of CME. Finally, we discuss tension-based regulation of endocytic clathrin coat formation during physiological processes.

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