Fa(c)t Checking: How Fatty Acids Shape Metabolism and Function of Macrophages and Dendritic Cells

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 2021 Mar 31

PMID 33788250

Citations 9

Authors

Luis Almeida

Bart Everts

Affiliations

Soon will be listed here.

Abstract

In recent years there have been major advances in our understanding of the role of free fatty acids (FAs) and their metabolism in shaping the functional properties of macrophages and DCs. This review presents the most recent insights into how cell intrinsic FA metabolism controls DC and macrophage function, as well as the current evidence of the importance of various exogenous FAs (such as polyunsaturated FAs and their oxidation products-prostaglandins, leukotrienes, and proresolving lipid mediators) in affecting DC and macrophage biology, by modulating their metabolic properties. Finally, we explore whether targeted modulation of FA metabolism of myeloid cells to steer their function could hold promise in therapeutic settings.

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