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Adolescent Transgender Females Present Impaired Semen Quality That Is Suitable for Intracytoplasmic Sperm Injection Even Before Initiating Gender-Affirming Hormone Treatment

Overview
Journal Reprod Sci
Publisher Springer
Date 2021 Mar 31
PMID 33788173
Citations 6
Authors
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Abstract

The present study aimed to determine the semen quality and cryopreservation outcomes among adolescent transgender females at the time of fertility preservation (FP) before initiating gender-affirming hormone (GAH) treatment. This retrospective cohort study included 26 adolescent transgender females who underwent FP in our Fertility Institute between 06/2013 and 10/2020. Pre-freezing semen parameters were compared to WHO 2010 reference values. Post-thaw semen parameters were used to determine the adequate assisted reproductive technology (ART). A multivariate linear regression analysis was performed to assess the impact of medical and lifestyle factors on semen quality. The mean age at which adolescent transgender females underwent FP was 16.2 ± 1.38 years. The median values of all semen parameters in our study group were significantly lower compared to the WHO data, including volume (1.46 mL vs 3.2 mL, respectively, P = 0.001 ), sperm concentration (28 × 10/mL vs 64 × 10/mL, P < 0.001), total sperm number (28.2 × 10 vs 196 × 10, P < 0.001), total motility (51.6% vs 62%, P < 0.001), and normal morphology (2% vs 14%, P < 0.001). The frequency of semen abnormalities was teratozoospermia 72%, hypospermia 52%, oligozoospermia 28%, and azoospermia 4%. The median post-thaw total motile count was 0.17 × 10/vial, and the quality was adequate only for ICSI in 87.7% of the thawed semen samples. No correlation was found between selected medical and lifestyle factors and poor semen parameters. Semen quality is strongly reduced among adolescent transgender females before hormone therapy and their stored sperm samples are suitable for intracytoplasmic sperm injection (ICSI) rather than conventional IVF/intrauterine insemination (IUI).

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References
1.
Edwards-Leeper L, Spack N . Psychological evaluation and medical treatment of transgender youth in an interdisciplinary "Gender Management Service" (GeMS) in a major pediatric center. J Homosex. 2012; 59(3):321-36. DOI: 10.1080/00918369.2012.653302. View

2.
Olson J, Schrager S, Belzer M, Simons L, Clark L . Baseline Physiologic and Psychosocial Characteristics of Transgender Youth Seeking Care for Gender Dysphoria. J Adolesc Health. 2015; 57(4):374-80. PMC: 5033041. DOI: 10.1016/j.jadohealth.2015.04.027. View

3.
Kreukels B, Haraldsen I, De Cuypere G, Richter-Appelt H, Gijs L, Cohen-Kettenis P . A European network for the investigation of gender incongruence: the ENIGI initiative. Eur Psychiatry. 2010; 27(6):445-50. DOI: 10.1016/j.eurpsy.2010.04.009. View

4.
Hembree W, Cohen-Kettenis P, Gooren L, Hannema S, Meyer W, Murad M . Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017; 102(11):3869-3903. DOI: 10.1210/jc.2017-01658. View

5.
Schneider F, Kliesch S, Schlatt S, Neuhaus N . Andrology of male-to-female transsexuals: influence of cross-sex hormone therapy on testicular function. Andrology. 2017; 5(5):873-880. DOI: 10.1111/andr.12405. View