COVID-19 and Thromboinflammation: Is There a Role for Statins?

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2021 Mar 31

PMID 33787678

Citations 8

Authors

Filipe Ferrari

Vitor M Martins

Marcelo Teixeira

Raul D Santos

Ricardo Stein

Affiliations

Soon will be listed here.

Abstract

The novel coronavirus disease (COVID-19) showed increased morbidity and mortality rates and worse prognosis in individuals with underlying chronic diseases, especially cardiovascular disease and its risk factors, such as hypertension, diabetes, and obesity. There is also evidence of possible links among COVID-19, myocardial infarction, and stroke. Emerging evidence suggests a pro-inflammatory milieu and hypercoagulable state in patients with this infection. Despite anticoagulation, a large proportion of patients requiring intensive care may develop life-threatening thrombotic complications. Indeed, the levels of some markers of hemostatic activation, such as D-dimer, are commonly elevated in COVID-19, indicating potential risk of deep vein thrombosis and pulmonary thromboembolism. In this review, we critically examine and discuss aspects of hypercoagulability and inflammation in COVID-19 and the possible benefits of statins in this scenario, with emphasis on their underlying molecular mechanisms. Moreover, we present recommendations on the use of antiviral drugs in combination with statins.

Citing Articles

Cholesterol and Cholesterol-Lowering Medications in COVID-19-An Unresolved Matter.

Grewal T, Nguyen M, Buechler C Int J Mol Sci. 2024; 25(19).

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Two Birds with One Stone: Drug Regime Targets Viral Pathogenesis Phases and COVID-19 ARDS at the Same Time.

Ghavami G, Sardari S Infect Disord Drug Targets. 2024; 24(8):e290124226467.

PMID: 38288808 DOI: 10.2174/0118715265270637240107153121.

Hypercoagulability in COVID-19: from an unknown beginning to future therapies.

Duca S, Costache A, Miftode R, Mitu O, Petris A, Costache I Med Pharm Rep. 2022; 95(3):236-242.

PMID: 36060499 PMC: 9387574. DOI: 10.15386/mpr-2195.

The Effect of Statins on Clinical Outcome Among Hospitalized Patients With COVID-19: A Multi-Centric Cohort Study.

Umakanthan S, Senthil S, John S, Madhavan M, Das J, Patil S Front Pharmacol. 2022; 13:742273.

PMID: 35865966 PMC: 9294274. DOI: 10.3389/fphar.2022.742273.

Biological Actions, Implications, and Cautions of Statins Therapy in COVID-19.

Liu C, Yan W, Shi J, Wang S, Peng A, Chen Y Front Nutr. 2022; 9:927092.

PMID: 35811982 PMC: 9257176. DOI: 10.3389/fnut.2022.927092.

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