Effect of the Anti-oestrogen Tamoxifen on the Development of Renal Cortical Necrosis Induced by Oestrone + Vasopressin Administration in Rats

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1988 Apr 1

PMID 3377960

Authors

J Kocsis

G Karacsony

S Karcsu

F A Laszlo

Affiliations

Soon will be listed here.

Abstract

Bilateral renal cortical necrosis was observed after vasopressin administration in rats pretreated with oestrone acetate. Histochemical (succinic dehydrogenase, trichrome, periodic acid Schiff) and electronmicroscopic methods were used to examine how the anti-oestrogen, Tamoxifen, influences the development of this renal cortical necrosis. The experiments revealed that in most rats vasopressin did not induce renal tubular necrosis if the anti-oestrogen was administered simultaneously, even during oestrogen pretreatment. The results suggest that oestrogen receptors in the kidney are involved in the induction of renal cortical necrosis by vasopressin.

References

Eckert R, Katzenellenbogen B . Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res. 1982; 42(1):139-44. View

Kocsis J, Karacsony G, Karcsu S, Laszlo F . Histochemical and ultrastructural study of renal cortical necrosis in rats treated with oestrone + vasopressin, and its prevention with a vasopressin antagonist. Br J Exp Pathol. 1987; 68(1):35-43. PMC: 2012994. View

Jordan V, Dix C, Rowsby L, Prestwich G . Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat. Mol Cell Endocrinol. 1977; 7(2):177-92. DOI: 10.1016/0303-7207(77)90066-1. View

Pasqualini J, Sumida C, Gelly C . [Formation of complex 3H-estradiol-macromolecules in cytosolic and nuclear fractions of fetal guinea-pig renal tissue]. C R Acad Hebd Seances Acad Sci D. 1973; 276(25):3359-62. View

McCall A, Stern J, DALE S, MELBY J . Adrenal steroidogenesis in methylandrostenediol-induced hypertension. Endocrinology. 1978; 103(1):1-5. DOI: 10.1210/endo-103-1-1. View

Korenman S, Dukes B . Specific estrogen binding by the cytoplasm fof human breast carcinoma. J Clin Endocrinol Metab. 1970; 30(5):639-45. DOI: 10.1210/jcem-30-5-639. View

Terenius L . Anti-oestrogens and breast cancer. Eur J Cancer (1965). 1971; 7(1):57-64. DOI: 10.1016/0014-2964(71)90095-8. View

Capony F, ROCHEFORT H . High-affinity binding of the antiestrogen [3H]tamoxifen to the 8S estradiol receptor. Mol Cell Endocrinol. 1978; 11(2):181-98. DOI: 10.1016/0303-7207(78)90006-0. View

Johnson J, Davis J, Baumber J, Schneider E . Effects of estrogens and progesterone on electrolyte balances in normal dogs. Am J Physiol. 1970; 219(6):1691-7. DOI: 10.1152/ajplegacy.1970.219.6.1691. View

10.

EDGREN R, Jones R, Peterson D, GILLEN A . Studies on the interactions of ethynyl oestradiol and norgestrel. Acta Endocrinol (Copenh). 1967; 54:Suppl 115:3-21. View

11.

JENSEN E, Block G, Smith S, Kyser K, Desombre E . Estrogen receptors and breast cancer response to adrenalectomy. Natl Cancer Inst Monogr. 1971; 34:55-70. View

12.

Katzenellenbogen B, Katzenellenbogen J, Ferguson E, Krauthammer N . Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628). J Biol Chem. 1978; 253(3):697-707. View

13.

Hahnel R, Twaddle E, Ratajczak T . The influence of synthetic anti-estrogens on the binding of tritiated estradiol-17beta by cytosols of human uterus and human breast carcinoma. J Steroid Biochem. 1973; 4(6):687-95. DOI: 10.1016/0022-4731(73)90044-7. View

14.

GREENBLATT R, Roy S, Mahesh V, BARFIELD W, JUNGCK E . Induction of ovulation. Am J Obstet Gynecol. 1962; 84:900-12. View

15.

Deutsch V, Frankl O, Drory Y, Eliahou H, Braf Z . Bilateral renal cortical necrosis with survival through the acute phase with a note on the value of selective nephroangiography. Am J Med. 1971; 50(6):828-34. DOI: 10.1016/0002-9343(71)90192-6. View

16.

Hiault C, Dequiedt P, Benoit O, Dognin C, MONNIER J, Cotteel M . [Postpartum renal cortical necrosis]. J Gynecol Obstet Biol Reprod (Paris). 1982; 11(7):839-48. View

17.

Feherty P, Farrer-Brown G, Kellie A . Oestradiol receptors in carcinoma and benign disease of the breast: an in vitro assay. Br J Cancer. 1971; 25(4):697-710. PMC: 2008872. DOI: 10.1038/bjc.1971.85. View

18.

Byrom F, Pratt O . Oxytocin and renal cortical necrosis. Lancet. 1959; 1(7076):753-4. DOI: 10.1016/s0140-6736(59)91827-6. View

19.

FOLCA P, GLASCOCK R, Irvine W . Studies with tritium-labelled hexoestrol in advanced breast cancer. Comparison of tissue accumulation of hexoestrol with response to bilateral adrenalectomy and oophorectomy. Lancet. 1961; 2(7206):796-8. DOI: 10.1016/s0140-6736(61)91088-1. View

20.

Lippman M, Bolan G . Oestrogen-responsive human breast cancer in long term tissue culture. Nature. 1975; 256(5518):592-3. DOI: 10.1038/256592a0. View