Functional Outcomes of Sleep Predict Cardiovascular Intermediary Outcomes and All-cause Mortality in Patients on Incident Hemodialysis

Overview

Journal J Clin Sleep Med

Specialties Neurology
Psychiatry

Date 2021 Mar 29

PMID 33779539

Citations 2

Authors

Jessica Fitzpatrick

Eric S Kerns

Esther D Kim

Stephen M Sozio

Bernard G Jaar

Michelle M Estrella

Larisa G Tereshchenko

Jose M Monroy-Trujillo

Rulan S Parekh

Ghada Bourjeily

Affiliations

Soon will be listed here.

Abstract

Study Objectives: Patients with end-stage kidney disease commonly experience sleep disturbances. Sleep disturbance has been inconsistently associated with mortality risk in patients on hemodialysis, but the burden of symptoms from sleep disturbances has emerged as a marker that may shed light on these discrepancies and guide treatment decisions. This study examines whether functional outcomes of sleep are associated with increased risk of intermediary cardiovascular outcomes or mortality among adults initiating hemodialysis.

Methods: In 228 participants enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease study, the Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), which assesses functional outcomes of daytime sleepiness, was administered within 6 months of enrollment. Intermediary cardiovascular outcomes included QT correction (ms), heart rate variance (ms), left ventricular mass index (g/m), and left ventricular hypertrophy. The association of FOSQ-10 score with all-cause mortality was examined using proportional hazards regression.

Results: Mean age was 55 years, and median body mass index was 28 kg/m (interquartile range, 24, 33), with 70% of patients being African Americans. Median FOSQ-10 score was 19.7 (interquartile range, 17.1, 20.0). A 10% lower FOSQ-10 score was associated with increased mortality risk (hazard ratio, 1.09; 95% confidence interval, 1.01-1.18). Lower FOSQ-10 scores were associated with longer QT correction duration and lower heart rate variance but not left ventricular mass index or left ventricular mass index.

Conclusions: In adults initiating dialysis, sleep-related functional impairment is common and is associated with intermediary cardiovascular disease measures and increased mortality risk. Future studies should assess the impact of screening for sleep disturbances in patients with end-stage kidney disease to identify individuals at increased risk for cardiovascular complications and death.

Citation: Fitzpatrick J, Kerns ES, Kim ED, et al. Functional outcomes of sleep predict cardiovascular intermediary outcomes and all-cause mortality in patients on incident hemodialysis. . 2021;17(8):1707-1715.

Citing Articles

Associations between sleep problems and cardiometabolic risk in maintenance hemodialysis patients: A multicenter study.

Yang H, Zhang Y, Li X, Liu Z, Bai Y, Qian G Heliyon. 2024; 10(6):e27377.

PMID: 38496884 PMC: 10944224. DOI: 10.1016/j.heliyon.2024.e27377.

Risk factors and prediction model of sleep disturbance in patients with maintenance hemodialysis: A single center study.

Xu R, Miao L, Ni J, Ding Y, Song Y, Yang C Front Neurol. 2022; 13:955352.

PMID: 35959399 PMC: 9360761. DOI: 10.3389/fneur.2022.955352.

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