Risk Factors for Postoperative Hypocalcaemia After Thyroidectomy: A Systematic Review and Meta-analysis

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2021 Mar 29

PMID 33779362

Citations 19

Authors

Zhimei Chen

Qiyuan Zhao

Jinlei Du

Ya Wang

Rongrong Han

Caijuan Xu

Xiaofang Chen

Min Shu

Affiliations

Soon will be listed here.

Abstract

Objective: A meta-analysis to investigate the risk factors for postoperative hypocalcaemia after thyroidectomy in adult patients.

Methods: A systematic search of publications in the electronic databases (PubMed®, The Cochrane Library, Web of Science, OVID and Embase®) from inception to June 2020 was conducted. Screening of titles, abstracts and full texts and data extraction were independently performed by two authors. The OR was selected as the pooled estimate.

Results: The analysis included 23 studies. Twelve significant risk factors for postoperative hypocalcaemia were identified: hypoparathyroidism, OR 5.58; total thyroidectomy, OR 3.59; hypomagnesaemia, OR 2.85; preoperative vitamin D deficiency, OR 2.32; female sex, OR 1.49; thyroid malignancy, OR 1.85; thyroiditis, OR 1.48; substernal multinodular goitres, OR 1.70; parathyroidectomy, OR 1.58; central compartment neck dissection, OR 1.17; modified radical neck dissection, OR 1.57; and central neck dissection, OR 1.54.

Conclusions: This meta-analysis provides moderate-to-high quality evidence that the 12 risk factors were predictive of postoperative hypocalcaemia, which should be monitored closely before thyroidectomy.

Citing Articles

Predictors of Postoperative Hypocalcemia and Hypoparathyroidism Following Thyroidectomy in Hanoi, Vietnam.

Do K, Duong P, Phung T, Duong Y, Hoang G, Le H Int J Endocrinol Metab. 2025; 22(2):e146358.

PMID: 40071247 PMC: 11892512. DOI: 10.5812/ijem-146358.

Post-thyroidectomy hypoparathyroidism: A clinical surgical dilemma.

AlQahtani S Saudi Med J. 2024; 45(12):1305-1311.

PMID: 39658114 PMC: 11629639. DOI: 10.15537/smj.2024.45.12.20240743.

Preoperative Calcium or Vitamin D Supplement in Thyroidectomy: A Systematic Review and Meta-Analysis.

Jullamusi W, Ratanaprasert N, Pongsapich W, Kasemsuk N Laryngoscope. 2024; 135(4):1267-1277.

PMID: 39460688 PMC: 11903918. DOI: 10.1002/lary.31860.

The use of prophylactic infusion of calcium gluconate compared to placebo in reducing the rate of early hypocalcaemia after total thyroidectomy: a double-blinded, randomized controlled trial.

Khoo K, Yeo A, Mirzan Asfian M, Ng K Gland Surg. 2024; 13(8):1378-1386.

PMID: 39282041 PMC: 11399017. DOI: 10.21037/gs-24-190.

The outcomes of parathyroid gland autotransplantation during thyroid surgery: a systematic review, meta-analysis and trial sequential analysis.

Koimtzis G, Stefanopoulos L, Geropoulos G, Papavramidis T Endocrine. 2024; 87(1):27-38.

PMID: 39182014 DOI: 10.1007/s12020-024-04011-y.

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