Health-related Physical Indicators and Self-rated Quality of Life in Older Adults with Neurocognitive Disorder

Overview

Journal Qual Life Res

Specialties Pharmacology
Rehabilitation Medicine

Date 2021 Mar 29

PMID 33778911

Citations 6

Authors

Flavia Borges-Machado

Duarte Barros

Laetitia Teixeira

Oscar Ribeiro

Joana Carvalho

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to identify the association between health-related physical indicators-sarcopenia-related factors, physical fitness, independence in activities of daily living (ADL) and habitual physical activity-and self-rated quality of life (QoL) in people with neurocognitive disorder (NCD).

Methods: This cross-sectional study included 115 participants (78.22 ± 7.48 years; 74.8% female) clinically diagnosed with NCD. Self-rated QoL was evaluated using The Quality of Life-Alzheimer's Disease (QoL-AD). Dual energy X-ray Absorptiometry, handgrip strength, Short Physical Performance Battery, and the 6-m Walk test were used to assess sarcopenia-related factors. Senior Fitness Test and One Leg Balance test, Barthel Index, Baecke Modified Habitual Physical Activity Questionnaire were used to determine physical fitness, independence in ADL and physical activity, respectively. Regressions analyses were performed to examine associations between these variables and QoL-AD.

Results: Data from univariable linear regression analysis revealed that self-rated QoL was associated with sarcopenia-related factors (lower body function, handgrip strength, gait speed, and appendicular skeletal muscle mass index-ASMI), physical fitness (upper-and-lower-body strength, agility/dynamic balance, cardiorespiratory fitness and body mass index), habitual physical activity and independence in ADL. Results from multivariable regression analysis showed that ASMI (B = 1.846, 95% CI 0.165-3.527, p = 0.032) and lower body function (B = 0.756, 95% CI 0.269-1.242, p = 0.003) were positively associated with self-rated QoL. These variables explained 20.1% of the variability seen in self-rated QoL, controlling for age, sex, marital status and education.

Conclusion: Sarcopenia-related factors, namely lower body function and ASMI, should be acknowledged in future research studies as critical health-related indicators associated with QoL in people with NCD.

Trial Registration: ClinicalTrials.gov-identifier number NCT04095962.

Citing Articles

Do physical fitness and cognitive function mediate the relationship between basic activities of daily living and quality of life in older adults with dementia?.

Barros D, Borges-Machado F, Silva-Fernandes A, Ribeiro O, Carvalho J Qual Life Res. 2023; 33(4):917-926.

PMID: 38112863 PMC: 10973068. DOI: 10.1007/s11136-023-03570-3.

Should Caregivers Also Be Included in Multicomponent Physical-Exercise-Based Interventions for People with a Neurocognitive Disorder? The Caregivers' Perspective.

Borges-Machado F, Barros D, Silva P, Marques P, Carvalho J, Ribeiro O Geriatrics (Basel). 2023; 8(5).

PMID: 37736886 PMC: 10514810. DOI: 10.3390/geriatrics8050086.

Does Multicomponent Physical Exercise Training Work for Dementia? Exploring the Effects on Cognition, Neuropsychiatric Symptoms, and Quality of Life.

Borges-Machado F, Teixeira L, Carvalho J, Ribeiro O J Geriatr Psychiatry Neurol. 2022; 36(5):376-385.

PMID: 36574616 PMC: 10394955. DOI: 10.1177/08919887221149152.

Construct validity and reliability of the 2-Minute Step Test (2MST) in individuals with low back pain.

de Jesus S, Bassi-Dibai D, Pontes-Silva A, da Silva de Araujo A, de Freitas Faria Silva S, Veneroso C BMC Musculoskelet Disord. 2022; 23(1):1062.

PMID: 36471309 PMC: 9721032. DOI: 10.1186/s12891-022-06050-w.

Impact of Different Resistance Training Protocols on Balance, Quality of Life and Physical Activity Level of Older Women.

Leitao L, Venturini G, Junior R, Monteiro E, Telles L, Araujo G Int J Environ Res Public Health. 2022; 19(18).

PMID: 36142038 PMC: 9517151. DOI: 10.3390/ijerph191811765.

References

Arvanitakis Z, Shah R, Bennett D . Diagnosis and Management of Dementia: Review. JAMA. 2019; 322(16):1589-1599. PMC: 7462122. DOI: 10.1001/jama.2019.4782. View

Browne J, OBoyle C, McGee H, JOYCE C, McDonald N, OMalley K . Individual quality of life in the healthy elderly. Qual Life Res. 1994; 3(4):235-44. DOI: 10.1007/BF00434897. View

Martyr A, Nelis S, Quinn C, Wu Y, Lamont R, Henderson C . Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia. Psychol Med. 2018; 48(13):2130-2139. DOI: 10.1017/S0033291718000405. View

Lawton M . Quality of life in Alzheimer disease. Alzheimer Dis Assoc Disord. 1994; 8 Suppl 3:138-50. View

Logsdon R, Gibbons L, McCurry S, Teri L . Assessing quality of life in older adults with cognitive impairment. Psychosom Med. 2002; 64(3):510-9. DOI: 10.1097/00006842-200205000-00016. View

Missotten P, Dupuis G, Adam S . Dementia-specific quality of life instruments: a conceptual analysis. Int Psychogeriatr. 2016; 28(8):1245-62. DOI: 10.1017/S1041610216000417. View

Ettema T, Droes R, de Lange J, Mellenbergh G, Ribbe M . A review of quality of life instruments used in dementia. Qual Life Res. 2005; 14(3):675-86. DOI: 10.1007/s11136-004-1258-0. View

Ojagbemi A, Akin-Ojagbemi N . Exercise and Quality of Life in Dementia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Appl Gerontol. 2017; 38(1):27-48. DOI: 10.1177/0733464817693374. View

ORourke H, Duggleby W, Fraser K, Jerke L . Factors that affect quality of life from the perspective of people with dementia: a metasynthesis. J Am Geriatr Soc. 2015; 63(1):24-38. DOI: 10.1111/jgs.13178. View

10.

Black B, Johnston D, Morrison A, Rabins P, Lyketsos C, Samus Q . Quality of life of community-residing persons with dementia based on self-rated and caregiver-rated measures. Qual Life Res. 2011; 21(8):1379-89. PMC: 3296880. DOI: 10.1007/s11136-011-0044-z. View

11.

Naglie G, Tomlinson G, Tansey C, Irvine J, Ritvo P, Black S . Utility-based Quality of Life measures in Alzheimer's disease. Qual Life Res. 2006; 15(4):631-43. DOI: 10.1007/s11136-005-4364-8. View

12.

Holopainen A, Siltanen H, Pohjanvuori A, Makisalo-Ropponen M, Okkonen E . Factors Associated with the Quality of Life of People with Dementia and with Quality of Life-Improving Interventions: Scoping Review. Dementia (London). 2017; 18(4):1507-1537. DOI: 10.1177/1471301217716725. View

13.

Byrne-Davis L, Bennett P, Wilcock G . How are quality of life ratings made? Toward a model of quality of life in people with dementia. Qual Life Res. 2006; 15(5):855-65. DOI: 10.1007/s11136-005-5416-9. View

14.

Logsdon R, McCurry S, Teri L . Evidence-Based Interventions to Improve Quality of Life for Individuals with Dementia. Alzheimers care today. 2008; 8(4):309-318. PMC: 2585781. View

15.

Hesseberg K, Bentzen H, Ranhoff A, Engedal K, Bergland A . Physical Fitness in Older People with Mild Cognitive Impairment and Dementia. J Aging Phys Act. 2015; 24(1):92-100. DOI: 10.1123/japa.2014-0202. View

16.

Lam F, Huang M, Liao L, Chung R, Kwok T, Pang M . Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review. J Physiother. 2018; 64(1):4-15. DOI: 10.1016/j.jphys.2017.12.001. View

17.

Umegaki H, Bonfiglio V, Komiya H, Watanabe K, Kuzuya M . Association Between Sarcopenia and Quality of Life in Patients with Early Dementia and Mild Cognitive Impairment. J Alzheimers Dis. 2020; 76(1):435-442. DOI: 10.3233/JAD-200169. View

18.

Pacifico J, Geerlings M, Reijnierse E, Phassouliotis C, Lim W, Maier A . Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis. Exp Gerontol. 2019; 131:110801. DOI: 10.1016/j.exger.2019.110801. View

19.

Waite S, Maitland S, Thomas A, Yarnall A . Sarcopenia and frailty in individuals with dementia: A systematic review. Arch Gerontol Geriatr. 2020; 92:104268. DOI: 10.1016/j.archger.2020.104268. View

20.

Marzetti E, Calvani R, Tosato M, Cesari M, Bari M, Cherubini A . Sarcopenia: an overview. Aging Clin Exp Res. 2017; 29(1):11-17. DOI: 10.1007/s40520-016-0704-5. View