A Randomized, Double-blind, Crossover Intervention Study of Traffic-related Air Pollution and Airway Inflammation in Healthy Adults

Overview

Journal Environ Epidemiol

Publisher Wolters Kluwer

Specialty Environmental Health

Date 2021 Mar 29

PMID 33778341

Authors

Bin Han

Nan Zhang

Ruojie Zhao

Liwen Zhang

Jia Xu

Wen Yang

Zhipeng Bai

Sverre Vedal

Affiliations

Soon will be listed here.

Abstract

Background: Traffic-related air pollution (TRAP) may increase the risk of respiratory disease. The components of TRAP that are responsible for its respiratory toxicity are largely unknown. The objective was to identify the component(s) of TRAP that cause airways inflammation using fractional exhaled nitric oxide (FE) and randomized interventions.

Methods: A randomized, double-blind, crossover intervention study was conducted in which 39 healthy university students spent 2 hours next to a busy road. During exposure, participants wore either a powered air-purifying respirator (PAPR) or an N95 facemask. PAPRs were fitted with a fine particle (PM) filter, a PM and volatile organic carbon (VOC) filter, or a sham filter, and were blinded to filter type. The four interventions (three PAPR filters and N95) were assigned randomly for each participant and separated by at least 1 week. FE was measured before and immediately after each roadside exposure, and at 1, 2, 4, and 6 hours after exposure.

Results: With the sham PAPR filter, the mean postexposure FE increased an average of 2.3 ppb (±4.4) compared with the pre-exposure level. Similar increases in FE were seen with both the PM PAPR filter and the N95 mask, but no increase was seen with the combination PM and VOC PAPR filter.

Conclusions: Because PAPR filters do not filter inorganic gases (e.g., NO or carbon monoxide), it is concluded that the VOC component of TRAP rather than either the particulate matter or the inorganic gases component is responsible for the airway inflammation caused by TRAP exposure.

References

Delfino R, Staimer N, Tjoa T, Gillen D, Schauer J, Shafer M . Airway inflammation and oxidative potential of air pollutant particles in a pediatric asthma panel. J Expo Sci Environ Epidemiol. 2013; 23(5):466-73. PMC: 4181605. DOI: 10.1038/jes.2013.25. View

Adar S, Adamkiewicz G, Gold D, Schwartz J, Coull B, Suh H . Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus trip. Environ Health Perspect. 2007; 115(4):507-12. PMC: 1852653. DOI: 10.1289/ehp.9386. View

McCreanor J, Cullinan P, Nieuwenhuijsen M, Stewart-Evans J, Malliarou E, Jarup L . Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med. 2007; 357(23):2348-58. DOI: 10.1056/NEJMoa071535. View

Mauderly J, Seilkop S . The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer.... Inhal Toxicol. 2014; 26(11):668-90. DOI: 10.3109/08958378.2014.920440. View

Pettit A, Kipen H, Laumbach R, Ohman-Strickland P, Kelly-McNeill K, Cepeda C . Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution. PLoS One. 2015; 10(12):e0144250. PMC: 4682772. DOI: 10.1371/journal.pone.0144250. View

Weichenthal S, Kulka R, Belisle P, Joseph L, Dubeau A, Martin C . Personal exposure to specific volatile organic compounds and acute changes in lung function and heart rate variability among urban cyclists. Environ Res. 2012; 118:118-23. DOI: 10.1016/j.envres.2012.06.005. View

Langrish J, Li X, Wang S, Lee M, Barnes G, Miller M . Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect. 2012; 120(3):367-72. PMC: 3295351. DOI: 10.1289/ehp.1103898. View

Sarnat J, Golan R, Greenwald R, Raysoni A, Kewada P, Winquist A . Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environ Res. 2014; 133:66-76. PMC: 4807398. DOI: 10.1016/j.envres.2014.05.004. View

Beelen R, Hoek G, Houthuijs D, van den Brandt P, Goldbohm R, Fischer P . The joint association of air pollution and noise from road traffic with cardiovascular mortality in a cohort study. Occup Environ Med. 2008; 66(4):243-50. DOI: 10.1136/oem.2008.042358. View

10.

Cakmak S, Dales R, Liu L, Kauri L, Lemieux C, Hebbern C . Residential exposure to volatile organic compounds and lung function: results from a population-based cross-sectional survey. Environ Pollut. 2014; 194:145-151. DOI: 10.1016/j.envpol.2014.07.020. View

11.

Pope 3rd C, Burnett R, Thun M, Calle E, Krewski D, Ito K . Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002; 287(9):1132-41. PMC: 4037163. DOI: 10.1001/jama.287.9.1132. View

12.

. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005; 171(8):912-30. DOI: 10.1164/rccm.200406-710ST. View

13.

Ye D, Klein M, Chang H, Sarnat J, Mulholland J, Edgerton E . Estimating Acute Cardiorespiratory Effects of Ambient Volatile Organic Compounds. Epidemiology. 2016; 28(2):197-206. PMC: 5285400. DOI: 10.1097/EDE.0000000000000607. View

14.

Shi J, Lin Z, Chen R, Wang C, Yang C, Cai J . Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial. Environ Health Perspect. 2016; 125(2):175-180. PMC: 5289918. DOI: 10.1289/EHP73. View

15.

Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G . Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med. 2014; 108(6):830-41. DOI: 10.1016/j.rmed.2014.02.005. View

16.

Dweik R, Boggs P, Erzurum S, Irvin C, Leigh M, Lundberg J . An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011; 184(5):602-15. PMC: 4408724. DOI: 10.1164/rccm.9120-11ST. View

17.

Brook R, Rajagopalan S, Pope 3rd C, Brook J, Bhatnagar A, Diez-Roux A . Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010; 121(21):2331-78. DOI: 10.1161/CIR.0b013e3181dbece1. View

18.

Martins P, Valente J, Papoila A, Caires I, Araujo-Martins J, Mata P . Airways changes related to air pollution exposure in wheezing children. Eur Respir J. 2011; 39(2):246-53. DOI: 10.1183/09031936.00025111. View

19.

Laumbach R, Kipen H, Ko S, Kelly-McNeil K, Cepeda C, Pettit A . A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability. Part Fibre Toxicol. 2014; 11:45. PMC: 4236446. DOI: 10.1186/s12989-014-0045-5. View