A Network Pharmacology to Explore the Mechanism of in the Treatment of Ischemic Stroke

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 Mar 29

PMID 33778069

Citations 7

Authors

Fangchen Liu

Ling Li

Jian Chen

Ying Wu

Yongbing Cao

Ping Zhong

Affiliations

Soon will be listed here.

Abstract

Background: is a valuable Chinese medicine, which is widely used in the clinical treatment of ischemic stroke. The present study is aimed at investigating its target and the mechanism involved in ischemic stroke treatment by network pharmacology.

Methods: Effective compounds of were collected using methods of network pharmacology and using the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM) and the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Potential compound targets were searched in the TCMSP and SwissTargetPrediction databases. Ischemic stroke-related disease targets were searched in the Drugbank, DisGeNet, OMIM, and TTD databases. These two types of targets were uploaded to the STRING database, and a network of their interaction (PPI) was built with its characteristics calculated, aiming to reveal a number of key targets. Hub genes were selected using a plug-in of the Cytoscape software, and Gene Ontology (GO) biological processes and pathway enrichment analyses of Kyoto Encyclopedia of Genes and Genomes (KEGG) were conducted using the clusterProfiler package of R language.

Results: Among 12 compounds, deoxycorticosterone, methyl cholate, and biliverdin were potentially effective components. A total of 344 compound targets and 590 ischemic stroke targets were found with 92 overlapping targets, including hub genes such as TP53, AKT, PIK2CA, MAPK3, MMP9, and MMP2. Biological functions of are associated with protein hydrolyzation, phosphorylation of serine/threonine residues of protein substrates, peptide bond hydrolyzation of peptides and proteins, hydrolyzation of intracellular second messengers, antioxidation and reduction, RNA transcription, and other biological processes.

Conclusion: may play a role in ischemic stroke by activating PI3K-AKT and MAPK signaling pathways, which are involved in regulating inflammatory response, cell apoptosis, and proliferation.

Citing Articles

A review of the 's intervention mechanism and clinical application in ischemic stroke.

Xu K, Deng B, Jia T, Ren M, Chen H, Zhang J Front Pharmacol. 2025; 15:1510779.

PMID: 39881874 PMC: 11775449. DOI: 10.3389/fphar.2024.1510779.

Retracted: A Network Pharmacology to Explore the Mechanism of in the Treatment of Ischemic Stroke.

International B Biomed Res Int. 2024; 2024:9768532.

PMID: 38550026 PMC: 10977125. DOI: 10.1155/2024/9768532.

Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology.

Gomez-Verjan J, Zepeda-Arzate E, Santiago-de-la-Cruz J, Estrella-Parra E, Rivero-Segura N Pharmaceuticals (Basel). 2023; 16(10).

PMID: 37895847 PMC: 10609914. DOI: 10.3390/ph16101376.

Editorial: Emerging and old viral diseases: Antiviral drug discovery from medicinal plants.

Rahmatullah M, Jahan R, Nissapatorn V, Pereira M, Wiart C Front Pharmacol. 2022; 13:976592.

PMID: 36059941 PMC: 9437638. DOI: 10.3389/fphar.2022.976592.

Network pharmacology-based analysis of the mechanism of for the treatment of type I allergy.

Li X, Li H, Wang T, Zhao Y, Shao Y, Sun Y Pharm Biol. 2022; 60(1):1224-1236.

PMID: 35760567 PMC: 9246231. DOI: 10.1080/13880209.2022.2086583.

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