Overnight Continuous Saline Bladder Irrigation After Resection of Bladder Tumor Does Not Improve Oncological Outcomes in Patients Who Have Received Intravesical Chemotherapy

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Mar 29

PMID 33777796

Citations 3

Authors

Yongjun Yang

Chao Liu

Xiaoting Yan

Jiawei Li

Xiaofeng Yang

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the safety and efficacy of overnight continuous saline bladder irrigation (CSBI) for patients who have received thulium laser resection of bladder tumor (TmLRBT) combined with immediate intravesical chemotherapy previously.

Methods: From October 2014 to June 2018, 235 patients with newly diagnosed non-muscle invasive bladder cancer (NMIBC) were included in this retrospective study. All patients received intravesical instillation of pirarubicin immediately after TmLRBT. The patients were divided into two groups according to the duration of postoperative bladder irrigation with normal saline. After immediate intravesical chemotherapy, patients in group 1 received overnight CSBI, while patients in group 2 did not receive overnight CSBI. Data on the time of initial tumor recurrence, recurrence-free survival (RFS) and progression-free survival (PFS) rates, and perioperative complications were collected and analyzed.

Results: Of 235 included patients (129 in group 1 and 106 in group 2), the median follow-up periods were 42 and 38 months, respectively. There were no significant differences in patients' baseline characteristics between the two groups. The RFS rates of patients in group 1 were 90.7, 82.7, and 76.8% at the end of the first, third, and fifth years, while the corresponding RFS rates of patients in group 2 were 87.7, 78.9, and 73.3%, respectively. Four patients in group 1 and five patients in group 2 experienced tumor progression. No significant differences between the two groups were observed in the time of initial tumor recurrence, RFS, and PFS rates. Only Grade I complications occurred in the two groups, and no significant difference was reached between the two groups.

Conclusions: For patients with NMIBC who have previously received TmLRBT combined with immediate intravesical chemotherapy, overnight CSBI may not improve oncological outcomes and reduce perioperative complications.

Citing Articles

The prognosis and safety of continuous saline bladder irrigation in patients after transurethral resection of bladder tumors: a systematic review and meta-analysis of comparative study.

Wang X, Wang Y, Che X, Zhou Z, Cheng B Updates Surg. 2023; 75(7):1795-1806.

PMID: 37188906 DOI: 10.1007/s13304-023-01525-4.

The impact of smoking on recurrence and progression of non-muscle invasive bladder cancer: a systematic review and meta-analysis.

Slusarczyk A, Zapala P, Zapala L, Radziszewski P J Cancer Res Clin Oncol. 2022; 149(6):2673-2691.

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En bloc transurethral resection of bladder tumors: A review of current techniques.

Croghan S, Compton N, Manecksha R, Cullen I, Daly P Can Urol Assoc J. 2021; 16(5):E287-E293.

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