MiR-22-3p/PGC1 Suppresses Breast Cancer Cell Tumorigenesis Via PPAR

Overview

Journal PPAR Res

Publisher Wiley

Date 2021 Mar 29

PMID 33777130

Citations 14

Authors

Xuehui Wang

Zhilu Yao

Lin Fang

Affiliations

Soon will be listed here.

Abstract

In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1 and finally regulate the PPAR pathway in BC. In conclusion, miR-22-3p/PGC1 suppresses BC cell tumorigenesis via PPAR, which may become a potential biomarker and therapeutic target.

Citing Articles

Serum hsa-miR-22-3p, hsa-miR-885-5p, Lipase-to-Amylase Ratio, C-Reactive Protein, CA19-9, and Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Advanced Pancreatic Ductal Adenocarcinoma.

Wnuk J, Hudy D, Strzelczyk J, Michalecki L, Dybek K, Gisterek-Grocholska I Curr Issues Mol Biol. 2025; 47(1).

PMID: 39852142 PMC: 11763715. DOI: 10.3390/cimb47010027.

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases.

Qian L, Zhu Y, Deng C, Liang Z, Chen J, Chen Y Signal Transduct Target Ther. 2024; 9(1):50.

PMID: 38424050 PMC: 10904817. DOI: 10.1038/s41392-024-01756-w.

Exosome microRNA-22 inhibiting proliferation, migration and invasion through regulating Twist1/CADM1 axis in osteosarcoma.

Ruan Q, Wang C, Wu Y, Zhu Q Sci Rep. 2024; 14(1):761.

PMID: 38191892 PMC: 10774347. DOI: 10.1038/s41598-023-50612-4.

MiR-22-3p suppresses NSCLC cell migration and EMT via targeting RAC1 expression.

Wang X, Wang X, Jiang T, Zhang Z, Xie N, Yang G Funct Integr Genomics. 2023; 23(3):281.

PMID: 37620594 PMC: 10449966. DOI: 10.1007/s10142-023-01211-z.

An angiogenesis-related lncRNA signature predicts the immune microenvironment and prognosis of breast cancer.

Wang Y, Liu C, Chen Y, Yang B, Chen X, Ma G Aging (Albany NY). 2023; 15(15):7616-7636.

PMID: 37543427 PMC: 10457060. DOI: 10.18632/aging.204930.

References

Wei W, Wang X, Yang M, Smith L, Dechow P, Sonoda J . PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 2010; 11(6):503-16. PMC: 3521515. DOI: 10.1016/j.cmet.2010.04.015. View

Sahin E, Colla S, Liesa M, Moslehi J, Muller F, Guo M . Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011; 470(7334):359-65. PMC: 3741661. DOI: 10.1038/nature09787. View

Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung U, Kubota N . PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004; 113(6):846-55. PMC: 362117. DOI: 10.1172/JCI19900. View

Huang R, Zhang J, Li M, Yan P, Yin H, Zhai S . The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer. PPAR Res. 2020; 2020:6527564. PMC: 7528029. DOI: 10.1155/2020/6527564. View

Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T . The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J Biol Chem. 2017; 292(26):10813-10823. PMC: 5491768. DOI: 10.1074/jbc.M116.772111. View

Chen H, Zhang Y, Cao X, Mou P . MiR-27a Facilitates Breast Cancer Progression via GSK-3β. Technol Cancer Res Treat. 2020; 19:1533033820965576. PMC: 7545786. DOI: 10.1177/1533033820965576. View

Bonofiglio D, Gabriele S, Aquila S, Qi H, Belmonte M, Catalano S . Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells. Breast Cancer Res Treat. 2008; 113(3):423-34. DOI: 10.1007/s10549-008-9944-1. View

Garzon R, Calin G, Croce C . MicroRNAs in Cancer. Annu Rev Med. 2009; 60:167-79. DOI: 10.1146/annurev.med.59.053006.104707. View

Zeng Y, Sang J . Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis. Oncotarget. 2018; 8(63):107273-107282. PMC: 5739812. DOI: 10.18632/oncotarget.21620. View

10.

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

11.

Wang L, Liu Q, Li F, Qiu J, Fan H, Ma H . Apoptosis induced by PGC-1β in breast cancer cells is mediated by the mTOR pathway. Oncol Rep. 2013; 30(4):1631-8. DOI: 10.3892/or.2013.2628. View

12.

Lin J, Handschin C, Spiegelman B . Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005; 1(6):361-70. DOI: 10.1016/j.cmet.2005.05.004. View

13.

Petr M, Stastny P, Zajac A, Tufano J, Maciejewska-Skrendo A . The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review. Int J Mol Sci. 2018; 19(5). PMC: 5983571. DOI: 10.3390/ijms19051472. View

14.

Yang P, Wang J, Cheng X, Chen J, Zhu H, Li X . PPAR- Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2. PPAR Res. 2019; 2019:8679271. PMC: 6699258. DOI: 10.1155/2019/8679271. View

15.

Victorino V, Barroso W, Assuncao A, Cury V, Jeremias I, Petroni R . PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol. 2015; 37(5):6035-44. DOI: 10.1007/s13277-015-4449-0. View

16.

Shao Y, Yao Y, Xiao P, Yang X, Zhang D . Serum miR-22 Could be a Potential Biomarker for the Prognosis of Breast Cancer. Clin Lab. 2019; 65(4). DOI: 10.7754/Clin.Lab.2018.180825. View

17.

Stefani G, Slack F . Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 2008; 9(3):219-30. DOI: 10.1038/nrm2347. View

18.

Cao J, Wang X, Wang D, Ma R, Li X, Feng H . PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells. Cancer Cell Int. 2019; 19:93. PMC: 6458718. DOI: 10.1186/s12935-019-0810-5. View

19.

Wang X, Ji C, Hu J, Deng X, Zheng W, Yu Y . Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway. J Exp Clin Cancer Res. 2021; 40(1):29. PMC: 7802350. DOI: 10.1186/s13046-021-01830-z. View

20.

Liu C, Lin J . PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai). 2011; 43(4):248-57. PMC: 3063079. DOI: 10.1093/abbs/gmr007. View