Unraveling the Role of Immune Checkpoints in Leishmaniasis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Mar 29

PMID 33776999

Citations 13

Authors

Rafael de Freitas E Silva

Esther von Stebut

Affiliations

Soon will be listed here.

Abstract

Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. is a parasitic protozoa which are transmitted by infected sandflies and in the host they mainly infect macrophages. Immunity elicited against those parasites is complex and immune checkpoints play a key role regulating its function. T cell receptors and their respective ligands, such as PD-1, CTLA-4, CD200, CD40, OX40, HVEM, LIGHT, 2B4 and TIM-3 have been characterized for their role in regulating adaptive immunity against different pathogens. However, the exact role those receptors perform during infections remains to be better determined. This article addresses the key role immune checkpoints play during infections, the limiting factors and translational implications.

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