Therapeutic Implications of Inflammasome in Inflammatory Bowel Disease

Overview

Journal FASEB J

Specialties Biology
Physiology

Date 2021 Mar 28

PMID 33774860

Citations 21

Authors

Vishal Khatri

Ramaswamy Kalyanasundaram

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however, hyperactive inflammatory and immune responses in the gut is shown to be one of the persistent causes of the disease. Human gut inflammasome, the activator of innate immune system is believed to be a primary underlying cause for the pathology and is largely associated with the progression of IBD. To manage IBD, there is a need to fully understand the role of inflammasome activation in IBD. Since inflammasome potentially play a significant role in IBD, systemic modulation of inflammasome may provide an effective therapeutic and clinical approach to control IBD symptoms. In this review, we have focused on this association between IBD and gut inflammasome, and recent advances in the research and therapeutic strategies for IBD. We have discussed inflammasomes and their components, outcomes from the experimental animals and human studies, inflammasome inhibitors, and developments in the inflammasome-targeted therapies for IBD.

Citing Articles

Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis.

Subramanian A, J A, T T, Kumarasamy V, Begum M, Sekar M J Inflamm Res. 2024; 17:10453-10470.

PMID: 39654856 PMC: 11626960. DOI: 10.2147/JIR.S483958.

Association of TMAO levels with indicators of ulcerative colitis activity.

Laryushina Y, Samoilova-Bedych N, Turgunova L, Marchenko A, Turgunov Y Caspian J Intern Med. 2024; 16(1):114-125.

PMID: 39619747 PMC: 11607106. DOI: 10.22088/cjim.16.1.114.

Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs.

Salim Abed H, Oghenemaro E, Kubaev A, Jeddoa Z, S R, Sharma S Cell Biochem Biophys. 2024; .

PMID: 39424765 DOI: 10.1007/s12013-024-01585-2.

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production.

Liang H, Tao S, Wang Y, Zhao J, Yan C, Wu Y Front Nutr. 2024; 11:1364739.

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Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31.

Lee Y, Yoon B, Son S, Cho E, Kim K, Choi E Cells. 2024; 13(8.

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