Automatic Wavelet-based Assessment of Behavioral Sleep Using Multichannel Electrocorticography in Rats

Overview

Journal Sleep Breath

Publisher Springer

Date 2021 Mar 26

PMID 33768413

Citations 4

Authors

Anastasiya Runnova

Maksim Zhuravlev

Anton Kiselev

Rodion Ukolov

Kirill Smirnov

Anatoly Karavaev

Evgenia Sitnikova

Affiliations

Soon will be listed here.

Abstract

Purpose: During the last decade, the reported prevalence of sleep-disordered breathing in adults has been rapidly increasing. Therefore, automatic methods of sleep assessment are of particular interest. In a framework of translational neuroscience, this study introduces a reliable automatic detection system of behavioral sleep in laboratory rats based on the signal recorded at the cortical surface without requiring electromyography.

Methods: Experimental data were obtained in 16 adult male WAG/Rij rats at the age of 9 months. Electrocorticographic signals (ECoG) were recorded in freely moving rats during the entire day (22.5 ± 2.2 h). Automatic wavelet-based assessment of behavioral sleep (BS) was proposed. The performance of this wavelet-based method was validated in a group of rats with genetic predisposition to absence epilepsy (n=16) based on visual analysis of their behavior in simultaneously recorded video.

Results: The accuracy of automatic sleep detection was 98% over a 24-h period. An automatic BS assessment method can be adjusted for detecting short arousals during sleep (microarousals) with various duration.

Conclusions: These findings suggest that automatic wavelet-based assessment of behavioral sleep can be used for assessment of sleep quality. Current analysis indicates a temporal relationship between microarousals, sleep, and epileptic discharges in genetically prone subjects.

Citing Articles

Automatic sleep-wake classification and Parkinson's disease recognition using multifeature fusion with support vector machine.

Shen Y, Huai B, Wang X, Chen M, Shen X, Han M CNS Neurosci Ther. 2024; 30(4):e14708.

PMID: 38600857 PMC: 11007385. DOI: 10.1111/cns.14708.

Adrenergic mechanisms of absence status epilepticus.

Sitnikova E Front Neurol. 2023; 14:1298310.

PMID: 38073616 PMC: 10703303. DOI: 10.3389/fneur.2023.1298310.

Spike-Wave Seizures, NREM Sleep and Micro-Arousals in WAG/Rij Rats with Genetic Predisposition to Absence Epilepsy: Developmental Aspects.

Zhuravlev M, Runnova A, Smirnov K, Sitnikova E Life (Basel). 2022; 12(4).

PMID: 35455067 PMC: 9026846. DOI: 10.3390/life12040576.

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij).

Sitnikova E Front Neurol. 2021; 12:766566.

PMID: 34803898 PMC: 8602200. DOI: 10.3389/fneur.2021.766566.

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