The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Mar 26

PMID 33768092

Citations 4

Authors

Soudeh Ghafouri-Fard

Atefe Abak

Mahdi Mohaqiq

Hamed Shoorei

Mohammad Taheri

Affiliations

Soon will be listed here.

Abstract

The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities.

Citing Articles

Long Non-Coding RNAs, Nuclear Receptors and Their Cross-Talks in Cancer-Implications and Perspectives.

Tiwari P, Tripathi L Cancers (Basel). 2024; 16(16).

PMID: 39199690 PMC: 11352509. DOI: 10.3390/cancers16162920.

IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review.

Szydlowska-Gladysz J, Gorecka A, Stepien J, Rysz I, Ben-Skowronek I Int J Mol Sci. 2024; 25(7).

PMID: 38612776 PMC: 11012406. DOI: 10.3390/ijms25073966.

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways.

Cai W, Ma Y, Song L, Cao N, Gao J, Zhou S BMC Cancer. 2023; 23(1):87.

PMID: 36698167 PMC: 9875405. DOI: 10.1186/s12885-023-10561-7.

SPINT1-AS1 Drives Cervical Cancer Progression via Repressing miR-214 Biogenesis.

Song H, Liu Y, Liang H, Jin X, Liu L Front Cell Dev Biol. 2021; 9:691140.

PMID: 34350182 PMC: 8326843. DOI: 10.3389/fcell.2021.691140.

References

Liu H, Su H, Wang X, Hao W . MiR-148a regulates bone marrow mesenchymal stem cells-mediated fracture healing by targeting insulin-like growth factor 1. J Cell Biochem. 2018; 120(2):1350-1361. DOI: 10.1002/jcb.27121. View

Oy G, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo G, Florenes V . Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma. Int J Cancer. 2009; 126(2):350-61. DOI: 10.1002/ijc.24727. View

Liu J, Jia Y, Jia L, Li T, Yang L, Zhang G . MicroRNA 615-3p Inhibits the Tumor Growth and Metastasis of NSCLC via Inhibiting IGF2. Oncol Res. 2018; 27(2):269-279. PMC: 7848428. DOI: 10.3727/096504018X15215019227688. View

Volkova E, Robinson B, Willis J, Currie M, Dachs G . Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells. Oncol Lett. 2014; 7(2):311-320. PMC: 3881921. DOI: 10.3892/ol.2013.1710. View

Li B, Ge L, Li M, Wang L, Li Z . miR-448 suppresses proliferation and invasion by regulating IGF1R in colorectal cancer cells. Am J Transl Res. 2016; 8(7):3013-22. PMC: 4969437. View

Wang L, Luan T, Zhou S, Lin J, Yang Y, Liu W . LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. Cancer Med. 2019; 8(9):4389-4403. PMC: 6675706. DOI: 10.1002/cam4.2335. View

Song R, Chen Y, Zhang Z, Bao Y, Yue W, Wang J . Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2009; 118(4-5):219-30. PMC: 2826506. DOI: 10.1016/j.jsbmb.2009.09.018. View

Pian L, Wen X, Kang L, Li Z, Nie Y, Du Z . Targeting the IGF1R Pathway in Breast Cancer Using Antisense lncRNA-Mediated Promoter cis Competition. Mol Ther Nucleic Acids. 2018; 12:105-117. PMC: 6023958. DOI: 10.1016/j.omtn.2018.04.013. View

Liu P, Hu Y, Ma L, Du M, Xia L, Hu Z . miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1. Biomed Pharmacother. 2015; 75:51-7. DOI: 10.1016/j.biopha.2015.08.010. View

10.

An L, Huang J, Han X, Wang J . Downregulation of lncRNA H19 sensitizes melanoma cells to cisplatin by regulating the miR-18b/IGF1 axis. Anticancer Drugs. 2020; 31(5):473-482. DOI: 10.1097/CAD.0000000000000888. View

11.

Watanabe N, Takaoka M, Sakurama K, Tomono Y, Hatakeyama S, Ohmori O . Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. Clin Cancer Res. 2008; 14(14):4631-9. DOI: 10.1158/1078-0432.CCR-07-4755. View

12.

Rosenzweig S . The Continuing Evolution of Insulin-like Growth Factor Signaling. F1000Res. 2020; 9. PMC: 7096212. DOI: 10.12688/f1000research.22198.1. View

13.

Yang Y, Liu X, Cheng L, Li L, Wei Z, Wang Z . Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2. Onco Targets Ther. 2020; 13:2247-2260. PMC: 7082711. DOI: 10.2147/OTT.S232795. View

14.

Guan J, Zhou Y, Mao F, Lin Y, Shen S, Zhang Y . MicroRNA‑320a suppresses tumor cell growth and invasion of human breast cancer by targeting insulin‑like growth factor 1 receptor. Oncol Rep. 2018; 40(2):849-858. DOI: 10.3892/or.2018.6517. View

15.

Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B . Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma. J Hematol Oncol. 2015; 8:10. PMC: 4333268. DOI: 10.1186/s13045-014-0105-1. View

16.

Li Y, Wang K, Song N, Hou K, Che X, Zhou Y . Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma. Invest New Drugs. 2019; 38(3):599-609. DOI: 10.1007/s10637-019-00802-7. View

17.

Zhu H, Xue C, Yao M, Wang H, Zhang P, Qian T . miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury. Cell Death Dis. 2018; 9(7):720. PMC: 6006361. DOI: 10.1038/s41419-018-0760-1. View

18.

Chen Z, Li X, Ye C, Chen H, Wang Z . Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling. Onco Targets Ther. 2020; 13:4035-4048. PMC: 7231768. DOI: 10.2147/OTT.S254133. View

19.

Zheng F, Tang Q, Zheng X, Wu J, Huang H, Zhang H . Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Exp Mol Med. 2018; 50(9):1-14. PMC: 6135838. DOI: 10.1038/s12276-018-0146-6. View

20.

Kim S, Jang H, Lee J, Park S, Park Y, Lim H . Clinical Significance of IGFBP-3 Methylation in Patients with Early Stage Gastric Cancer. Transl Oncol. 2015; 8(4):288-94. PMC: 4562974. DOI: 10.1016/j.tranon.2015.06.001. View