Impact of Alcohol on Bone Health, Homeostasis and Fracture Repair

Overview

Journal Curr Pathobiol Rep

Specialty Pathology

Date 2021 Mar 26

PMID 33767923

Citations 4

Authors

Jonathan M Eby

Farah Sharieh

John J Callaci

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.

Recent Findings: Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.

Summary: This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.

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References

Diez A, Serrano S, Cucurull J, Marinoso L, Bosch J, Puig J . Acute effects of ethanol on mineral metabolism and trabecular bone in Sprague-Dawley rats. Calcif Tissue Int. 1997; 61(2):168-71. DOI: 10.1007/s002239900317. View

Johnston J, McGovern S . Alcohol related falls: an interesting pattern of injuries. Emerg Med J. 2004; 21(2):185-8. PMC: 1726307. DOI: 10.1136/emj.2003.006130. View

Turner R, Kidder L, Kennedy A, Evans G, Sibonga J . Moderate alcohol consumption suppresses bone turnover in adult female rats. J Bone Miner Res. 2001; 16(3):589-94. DOI: 10.1359/jbmr.2001.16.3.589. View

Raheja L, Genetos D, Yellowley C . Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochem Biophys Res Commun. 2007; 366(4):1061-6. DOI: 10.1016/j.bbrc.2007.12.076. View

Lauing K, Himes R, Rachwalski M, Strotman P, Callaci J . Binge alcohol treatment of adolescent rats followed by alcohol abstinence is associated with site-specific differences in bone loss and incomplete recovery of bone mass and strength. Alcohol. 2008; 42(8):649-56. PMC: 2633927. DOI: 10.1016/j.alcohol.2008.08.005. View

Ronis M, Mercer K, Chen J . Effects of nutrition and alcohol consumption on bone loss. Curr Osteoporos Rep. 2011; 9(2):53-9. PMC: 3190131. DOI: 10.1007/s11914-011-0049-0. View

Johnell O, Kanis J . An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17(12):1726-33. DOI: 10.1007/s00198-006-0172-4. View

Savola O, Niemela O, Hillbom M . Alcohol intake and the pattern of trauma in young adults and working aged people admitted after trauma. Alcohol Alcohol. 2005; 40(4):269-73. DOI: 10.1093/alcalc/agh159. View

Chen Y, Chen L, Yin Q, Gao H, Dong P, Zhang X . Reciprocal interferences of TNF-α and Wnt1/β-catenin signaling axes shift bone marrow-derived stem cells towards osteoblast lineage after ethanol exposure. Cell Physiol Biochem. 2013; 32(3):755-65. DOI: 10.1159/000354477. View

10.

Santori C, Ceccanti M, Diacinti D, Attilia M, Toppo L, DErasmo E . Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. J Endocrinol Invest. 2008; 31(4):321-6. DOI: 10.1007/BF03346365. View

11.

Watt J, Alund A, Pulliam C, Mercer K, Suva L, Chen J . NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis. J Pharmacol Exp Ther. 2018; 366(1):46-57. PMC: 5988025. DOI: 10.1124/jpet.117.247262. View

12.

Wezeman F, Emanuele M, Moskal S, Steiner J, LaPaglia N . Alendronate administration and skeletal response during chronic alcohol intake in the adolescent male rat. J Bone Miner Res. 2000; 15(10):2033-41. DOI: 10.1359/jbmr.2000.15.10.2033. View

13.

Iyer S, Ambrogini E, Bartell S, Han L, Roberson P, de Cabo R . FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest. 2013; 123(8):3409-19. PMC: 3726166. DOI: 10.1172/JCI68049. View

14.

Shirley D, Marsh D, Jordan G, McQuaid S, Li G . Systemic recruitment of osteoblastic cells in fracture healing. J Orthop Res. 2005; 23(5):1013-21. DOI: 10.1016/j.orthres.2005.01.013. View

15.

Alund A, Mercer K, Pulliam C, Suva L, Chen J, Badger T . Partial Protection by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice. Alcohol Clin Exp Res. 2016; 41(1):46-56. PMC: 5521216. DOI: 10.1111/acer.13284. View

16.

Nyquist F, Berglund M, NILSSON B, Obrant K . Nature and healing of tibial shaft fractures in alcohol abusers. Alcohol Alcohol. 1997; 32(1):91-5. DOI: 10.1093/oxfordjournals.alcalc.a008240. View

17.

Kanis J, Johansson H, Johnell O, Oden A, De Laet C, Eisman J . Alcohol intake as a risk factor for fracture. Osteoporos Int. 2004; 16(7):737-42. DOI: 10.1007/s00198-004-1734-y. View

18.

Perry 3rd H, Horowitz M, Fleming S, Kaiser F, Patrick P, Morley J . Effect of recent alcohol intake on parathyroid hormone and mineral metabolism in men. Alcohol Clin Exp Res. 1998; 22(6):1369-75. View

19.

Duckworth A, Bennet S, Aderinto J, Keating J . Fixation of intracapsular fractures of the femoral neck in young patients: risk factors for failure. J Bone Joint Surg Br. 2011; 93(6):811-6. DOI: 10.1302/0301-620X.93B6.26432. View

20.

Atashi F, Modarressi A, Pepper M . The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review. Stem Cells Dev. 2015; 24(10):1150-63. PMC: 4424969. DOI: 10.1089/scd.2014.0484. View