» Articles » PMID: 33766129

Long Non-coding RNA LNC_000641 Regulates Pseudorabies Virus Replication

Overview
Journal Vet Res
Publisher Biomed Central
Date 2021 Mar 26
PMID 33766129
Citations 9
Authors
Affiliations
Soon will be listed here.
Abstract

Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. The lncRNAs regulation of pseudorabies virus (PRV) infection has rarely been reported so far. Using RNA sequencing analysis, 225 lncRNAs with significant altered expressions in 3D4/21 cells infected with PRV (ZJ01) were identified. Five lncRNAs upregulated in PRV-infected cells were verified in cells infected with different PRV strains by qRT-PCR. By down- and up-regulation of lnc641, the accelerating effect of lnc641 on PRV replication was confirmed. Furthermore, we found that lnc641 regulated PRV replication by inhibiting the JAK-STAT1 pathway. This study suggests that lnc641 could be a new host factor target for developing antiviral therapies against PRV infection.

Citing Articles

Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection.

Zhang S, Li J, Wang M, Jia R, Chen S, Liu M Front Microbiol. 2025; 16:1539903.

PMID: 39973927 PMC: 11835999. DOI: 10.3389/fmicb.2025.1539903.


A previously unidentified circRNA inhibits virus replication by regulating the miR-24-3p/KEAP1 axis.

Li H, Du L, Li J, Huang Y, Lu C, Deng T PLoS Pathog. 2024; 20(12):e1012712.

PMID: 39689152 PMC: 11651552. DOI: 10.1371/journal.ppat.1012712.


Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.

Xu B, He Y, Yang R, Li J, Wang X Int J Mol Sci. 2024; 25(6).

PMID: 38542512 PMC: 10970867. DOI: 10.3390/ijms25063539.


Regulatory Non-Coding RNAs during Porcine Viral Infections: Potential Targets for Antiviral Therapy.

Li F, Yu H, Qi A, Zhang T, Huo Y, Tu Q Viruses. 2024; 16(1).

PMID: 38257818 PMC: 10818342. DOI: 10.3390/v16010118.


Aid or Antagonize: Nuclear Long Noncoding RNAs Regulate Host Responses and Outcomes of Viral Infections.

Kulkarni V, Jayakumar S, Mohan M, Kulkarni S Cells. 2023; 12(7).

PMID: 37048060 PMC: 10093752. DOI: 10.3390/cells12070987.


References
1.
He W, Auclert L, Zhai X, Wong G, Zhang C, Zhu H . Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus. J Infect Dis. 2018; 219(11):1705-1715. DOI: 10.1093/infdis/jiy731. View

2.
Wapinski O, Chang H . Long noncoding RNAs and human disease. Trends Cell Biol. 2011; 21(6):354-61. DOI: 10.1016/j.tcb.2011.04.001. View

3.
Jin Y, Zhang K, Huang W, Tang W, Li H, Dong W . Identification of functional lncRNAs in pseudorabies virus type II infected cells. Vet Microbiol. 2020; 242:108564. DOI: 10.1016/j.vetmic.2019.108564. View

4.
Gomez J, Wapinski O, Yang Y, Bureau J, Gopinath S, Monack D . The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 2013; 152(4):743-54. PMC: 3577098. DOI: 10.1016/j.cell.2013.01.015. View

5.
Fortes P, Morris K . Long noncoding RNAs in viral infections. Virus Res. 2015; 212:1-11. PMC: 4744516. DOI: 10.1016/j.virusres.2015.10.002. View