Long Non-coding RNA LNC_000641 Regulates Pseudorabies Virus Replication

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2021 Mar 26

PMID 33766129

Citations 9

Authors

Linlin Fang

Yanni Gao

Xing Liu

Juan Bai

Ping Jiang

Xianwei Wang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. The lncRNAs regulation of pseudorabies virus (PRV) infection has rarely been reported so far. Using RNA sequencing analysis, 225 lncRNAs with significant altered expressions in 3D4/21 cells infected with PRV (ZJ01) were identified. Five lncRNAs upregulated in PRV-infected cells were verified in cells infected with different PRV strains by qRT-PCR. By down- and up-regulation of lnc641, the accelerating effect of lnc641 on PRV replication was confirmed. Furthermore, we found that lnc641 regulated PRV replication by inhibiting the JAK-STAT1 pathway. This study suggests that lnc641 could be a new host factor target for developing antiviral therapies against PRV infection.

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