Chronic Exposure to PM2.5 Aggravates SLE Manifestations in Lupus-prone Mice

Overview

Journal Part Fibre Toxicol

Publisher Biomed Central

Specialty Toxicology

Date 2021 Mar 26

PMID 33766080

Citations 9

Authors

Victor Yuji Yariwake

Janaina Iannicelli Torres

Amandda Rakell Peixoto Dos Santos

Sarah Cristina Ferreira Freitas

Katia De Angelis

Sylvia Costa Lima Farhat

Niels Olsen Saraiva Camara

Mariana Matera Veras

Affiliations

Soon will be listed here.

Abstract

Background: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed.

Results: Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA.

Conclusions: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

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References

Lane P, Steffes M, MAUER S . Estimation of glomerular volume: a comparison of four methods. Kidney Int. 1992; 41(4):1085-9. DOI: 10.1038/ki.1992.165. View

de Brito J, Macchione M, Yoshizaki K, Toledo-Arruda A, Saraiva-Romanholo B, de Fatima Andrade M . Acute cardiopulmonary effects induced by the inhalation of concentrated ambient particles during seasonal variation in the city of São Paulo. J Appl Physiol (1985). 2014; 117(5):492-9. DOI: 10.1152/japplphysiol.00156.2014. View

Ghodke-Puranik Y, Niewold T . Immunogenetics of systemic lupus erythematosus: A comprehensive review. J Autoimmun. 2015; 64:125-36. PMC: 4628859. DOI: 10.1016/j.jaut.2015.08.004. View

Hill T, Jorgenson A, Ore P, Balistreri K, Clark B . Air quality and life expectancy in the United States: An analysis of the moderating effect of income inequality. SSM Popul Health. 2019; 7:100346. PMC: 6321951. DOI: 10.1016/j.ssmph.2018.100346. View

Parks C, Santos A, Barbhaiya M, Costenbader K . Understanding the role of environmental factors in the development of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2017; 31(3):306-320. PMC: 5729939. DOI: 10.1016/j.berh.2017.09.005. View

Yoshizaki K, Fuziwara C, Brito J, Santos T, Kimura E, Correia A . The effects of urban particulate matter on the nasal epithelium by gender: An experimental study in mice. Environ Pollut. 2016; 213:359-369. DOI: 10.1016/j.envpol.2016.02.044. View

Guariento A, Silva M, Tassetano P, Rocha S, Campos L, Valente M . [Liver and spleen biometrics in childhood-onset systemic lupus erythematosus patients]. Rev Bras Reumatol. 2015; 55(4):346-51. DOI: 10.1016/j.rbr.2014.12.010. View

Cooper G, Gilbert K, Greidinger E, James J, Pfau J, Reinlib L . Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect. 2008; 116(6):695-702. PMC: 2430222. DOI: 10.1289/ehp.11092. View

Yin P, Brauer M, Cohen A, Wang H, Li J, Burnett R . The effect of air pollution on deaths, disease burden, and life expectancy across China and its provinces, 1990-2017: an analysis for the Global Burden of Disease Study 2017. Lancet Planet Health. 2020; 4(9):e386-e398. PMC: 7487771. DOI: 10.1016/S2542-5196(20)30161-3. View

10.

Montes G, JUNQUEIRA L . The use of the Picrosirius-polarization method for the study of the biopathology of collagen. Mem Inst Oswaldo Cruz. 1991; 86 Suppl 3:1-11. DOI: 10.1590/s0074-02761991000700002. View

11.

Tavera Busso I, Mateos A, Juncos L, Canals N, Carreras H . Kidney damage induced by sub-chronic fine particulate matter exposure. Environ Int. 2018; 121(Pt 1):635-642. DOI: 10.1016/j.envint.2018.10.007. View

12.

Fang X, Zaman M, Guo X, Ding H, Xie C, Zhang X . Role of Hepatic Deposited Immunoglobulin G in the Pathogenesis of Liver Damage in Systemic Lupus Erythematosus. Front Immunol. 2018; 9:1457. PMC: 6026631. DOI: 10.3389/fimmu.2018.01457. View

13.

Zhao C, Mei Y, Wu G, Mao Y, Wu Q, Dan Y . Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study. Lupus. 2019; 28(13):1541-1548. DOI: 10.1177/0961203319882503. View

14.

Lisnevskaia L, Murphy G, Isenberg D . Systemic lupus erythematosus. Lancet. 2014; 384(9957):1878-1888. DOI: 10.1016/S0140-6736(14)60128-8. View

15.

Tsokos G . Systemic lupus erythematosus. N Engl J Med. 2011; 365(22):2110-21. DOI: 10.1056/NEJMra1100359. View

16.

Farhat S, Silva C, Orione M, Campos L, Sallum A, Braga A . Air pollution in autoimmune rheumatic diseases: a review. Autoimmun Rev. 2011; 11(1):14-21. DOI: 10.1016/j.autrev.2011.06.008. View

17.

Pick E, Keisari Y . A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods. 1980; 38(1-2):161-70. DOI: 10.1016/0022-1759(80)90340-3. View

18.

Schnaper H . The Tubulointerstitial Pathophysiology of Progressive Kidney Disease. Adv Chronic Kidney Dis. 2017; 24(2):107-116. PMC: 5351778. DOI: 10.1053/j.ackd.2016.11.011. View

19.

Zhao C, Xu Z, Wu G, Mao Y, Liu L, Qian-Wu . Emerging role of air pollution in autoimmune diseases. Autoimmun Rev. 2019; 18(6):607-614. DOI: 10.1016/j.autrev.2018.12.010. View

20.

Di Domenico M, Benevenuto S, Tomasini P, Yariwake V, de Oliveira Alves N, Rahmeier F . Concentrated ambient fine particulate matter (PM) exposure induce brain damage in pre and postnatal exposed mice. Neurotoxicology. 2020; 79:127-141. DOI: 10.1016/j.neuro.2020.05.004. View