Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2021 Mar 25

PMID 33762829

Citations 8

Authors

Jian Sun

Weiwei Sheng

Yuteng Ma

Ming Dong

Affiliations

Soon will be listed here.

Abstract

Local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. It is generally believed that this malignant behavior is stimulated by epithelial-mesenchymal transition (EMT). Musashi (MSI) RNA-binding proteins, belonging to the evolutionarily conserved RNA-binding proteins (RBP) family, were originally discovered to regulate asymmetric cell division during embryonic development. Recently, Musashi-2 (MSI2), as a key member of MSI family, has been prevalently reported to be tightly associated with the advanced clinical stage of several cancers. Multiple oncogenic signaling pathways mediated by MSI2 play vital roles in EMT. Here, we systematically reviewed the detailed role and signal networks of MSI2 in regulating cancer development, especially in EMT signal transduction, involving EGF, TGF-β, Notch, and Wnt pathways.

Citing Articles

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References

Emadi-Baygi M, Nikpour P, Mohammad-Hashem F, Maracy M, Haghjooy-Javanmard S . MSI2 expression is decreased in grade II of gastric carcinoma. Pathol Res Pract. 2013; 209(11):689-91. DOI: 10.1016/j.prp.2013.07.008. View

Wang M, Sun X, Zhou Y, Zhang K, Lu Y, Liu J . Suppression of Musashi‑2 by the small compound largazole exerts inhibitory effects on malignant cells. Int J Oncol. 2020; 56(5):1274-1283. DOI: 10.3892/ijo.2020.4993. View

Sanchez-Tillo E, Lazaro A, Torrent R, Cuatrecasas M, Vaquero E, Castells A . ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene. 2010; 29(24):3490-500. DOI: 10.1038/onc.2010.102. View

Yang C, Zhang W, Wang L, Kazobinka G, Han X, Li B . Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway. Lab Invest. 2016; 96(9):950-8. DOI: 10.1038/labinvest.2016.71. View

Zong Z, Zhou T, Rao L, Jiang Z, Li Y, Hou Z . Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer. Cancer Med. 2016; 5(4):623-30. PMC: 4831280. DOI: 10.1002/cam4.624. View

Kawahara H, Imai T, Imataka H, Tsujimoto M, Matsumoto K, Okano H . Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J Cell Biol. 2008; 181(4):639-53. PMC: 2386104. DOI: 10.1083/jcb.200708004. View

Criswell T, Arteaga C . Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility. J Biol Chem. 2007; 282(44):32491-500. DOI: 10.1074/jbc.M704434200. View

Siddall N, McLaughlin E, Marriner N, Hime G . The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. Proc Natl Acad Sci U S A. 2006; 103(22):8402-7. PMC: 1570104. DOI: 10.1073/pnas.0600906103. View

Yewale C, Baradia D, Vhora I, Patil S, Misra A . Epidermal growth factor receptor targeting in cancer: a review of trends and strategies. Biomaterials. 2013; 34(34):8690-707. DOI: 10.1016/j.biomaterials.2013.07.100. View

10.

Wuebben E, Mallanna S, Cox J, Rizzino A . Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells. PLoS One. 2012; 7(4):e34827. PMC: 3319613. DOI: 10.1371/journal.pone.0034827. View

11.

Minuesa G, Albanese S, Xie W, Kazansky Y, Worroll D, Chow A . Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019; 10(1):2691. PMC: 6584500. DOI: 10.1038/s41467-019-10523-3. View

12.

Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y . A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins. Comb Chem High Throughput Screen. 2014; 17(7):596-609. PMC: 4135234. DOI: 10.2174/1386207317666140609122714. View

13.

Wang Z, Wang C, Liu W, Ai Z . Emerging roles of the long non-coding RNA 01296/microRNA-143-3p/MSI2 axis in development of thyroid cancer. Biosci Rep. 2019; 39(11). PMC: 6881211. DOI: 10.1042/BSR20182376. View

14.

Liu Y, Fan Y, Wang X, Huang Z, Shi K, Zhou B . Musashi-2 is a prognostic marker for the survival of patients with cervical cancer. Oncol Lett. 2018; 15(4):5425-5432. PMC: 5844186. DOI: 10.3892/ol.2018.8077. View

15.

Yang S, Sheng L, Xu K, Wang Y, Zhu H, Zhang P . Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway. Mol Med Rep. 2017; 17(1):522-530. DOI: 10.3892/mmr.2017.7892. View

16.

Choi Y, Kim K, Lee J, Chun Y, An I, An S . DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer. Oncogene. 2016; 36(20):2802-2812. PMC: 5442418. DOI: 10.1038/onc.2016.441. View

17.

Saad S, Stanners S, Yong R, Tang O, Pollock C . Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int J Biochem Cell Biol. 2010; 42(7):1115-22. DOI: 10.1016/j.biocel.2010.03.016. View

18.

Herbst R . Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004; 59(2 Suppl):21-6. DOI: 10.1016/j.ijrobp.2003.11.041. View

19.

Shi Y, Massague J . Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003; 113(6):685-700. DOI: 10.1016/s0092-8674(03)00432-x. View

20.

Zhang H, Tan S, Wang J, Chen S, Quan J, Xian J . Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. Exp Cell Res. 2013; 320(1):119-27. DOI: 10.1016/j.yexcr.2013.09.009. View