The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2021 Mar 24

PMID 33758533

Citations 7

Authors

Yan Chen

Yan-Xia Chen

Chong Huang

Zhi-Bing Duan

Cheng-Yun Xu

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to investigate the clinical value of serum Klotho and FGF23 in cardiac valve calcification in patients with chronic kidney disease (CKD).

Methods: In the present study, 180 patients with CKD, who were admitted to the department of nephrology of our hospital on April 1, 2016 (solstice, 2019), were selected as the main subjects. According to the CKD stage, these patients were divided into three groups: CKD2~3 group, CKD4 group, and CKD5 group. In each group, ultrasound was used to evaluate the cardiac valve calcification, and the independent risk factors for cardiac valve calcification were analyzed by Logistic regression.

Results: The levels of hemoglobin and blood calcium in CKD2~3 patients were higher than those in CKD4 and CKD5 patients, and the levels of hemoglobin and blood calcium in CKD5 patients were higher than those in CKD4 patients (<0.05). Albumin was lower in CKD2~3 patients when compared to CKD5 patients while albumin was higher in CKD5 patients when compared to CKD4 patients (<0.05). The serum levels of FGF23 was lower in CKD2~3 patients when compared to CKD4 and CKD5 patients while the serum levels of FGF23 was lower in CKD4 patients when compared to CKD5 patients (<0.05). The serum levels of Klotho was higher in CKD2~3 patients, when compared to CKD4 and CKD5 patients, while the serum levels of Klotho was higher in CKD4 patients, when compared to CKD5 patients (<0.05). The logistic regression analysis revealed that GFR, serum creatinine, FGF23 and Klotho were independent risk factors for cardiac valve calcification in patients with CKD.

Conclusion: With the decrease of GFR in CKD patients, the serum levels of FGF23 increases, while the serum levels of Klotho decreases. Furthermore, the serum levels of FGF23 and Klotho are affected by various factors, and the levels of FGF23 and Klotho in CKD patients are negatively correlated. GFR, serum creatinine, FGF23 and Klotho are independent risk factors for heart valve calcification in patients with CKD.

Citing Articles

Correlation between soluble klotho and chronic kidney disease-mineral and bone disorder in chronic kidney disease: a meta-analysis.

Fan Z, Wei X, Zhu X, Yang K, Tian L, Du Y Sci Rep. 2024; 14(1):4477.

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Current and Emerging Markers and Tools Used in the Diagnosis and Management of Chronic Kidney Disease-Mineral and Bone Disorder in Non-Dialysis Adult Patients.

Fusaro M, Pereira L, Bover J J Clin Med. 2023; 12(19).

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The controversy of klotho as a potential biomarker in chronic kidney disease.

Yu L, Li S, Sha M, Kong J, Ye J, Liu Q Front Pharmacol. 2022; 13:931746.

PMID: 36210812 PMC: 9532967. DOI: 10.3389/fphar.2022.931746.

Increased TGFβ1 and SMAD3 Contribute to Age-Related Aortic Valve Calcification.

Chakrabarti M, Bhattacharya A, Gebere M, Johnson J, Ayub Z, Chatzistamou I Front Cardiovasc Med. 2022; 9:770065.

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High C-Terminal Fibroblast Growth Factor-23, Intact Parathyroid Hormone, and Interleukin-6 as Determinants of Valvular Calcification in Regular Hemodialysis Patients.

Kandarini Y, Mahadita G, Herawati S, Wibhuti I, Widiana I, Ayu N Int J Gen Med. 2022; 15:4227-4236.

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