Bio-multifunctional Noncovalent Porphyrin Functionalized Carbon-based Nanocomposite

Overview

Journal Sci Rep

Specialty Science

Date 2021 Mar 24

PMID 33758300

Citations 8

Authors

Navid Rabiee

Mojtaba Bagherzadeh

Amir Mohammad Ghadiri

Yousef Fatahi

Nafiseh Baheiraei

Moein Safarkhani

Abdullah Aldhaher

Rassoul Dinarvand

Affiliations

Soon will be listed here.

Abstract

Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNiS, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π-π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin' nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor-acceptor relationship between the d transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene loading , and transfections. The reason for this phenomenon was optimized to increase the EGFP by up to 17.9%. Furthermore, the sensing ability of the nanocomposite towards HO was investigated. In this regard, the limit of detection of the HO obtained 10 µM. Also, the in situ biosensing ability in the HEK-293 and PC12 cell lines was evaluated by the addition of PMA. The nanocomposite showed the ability to detect the released HO after adding the minimum amount of 120 ng/mL of the PMA.

Citing Articles

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Bioactive hybrid metal-organic framework (MOF)-based nanosensors for optical detection of recombinant SARS-CoV-2 spike antigen.

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