Interleukin-10 Gene Promoter Polymorphisms and Susceptibility to Asthma: Systematic Review and Meta-analysis

Overview

Journal Biochem Genet

Specialty Molecular Biology

Date 2021 Mar 23

PMID 33755871

Citations 4

Authors

Danyal Imani

Navid Dashti

Arash Parvari

Sajad Shafiekhani

Fatemeh Alebrahim

Bahman Razi

Masoud Hassanzadeh Makoui

Morteza Motallebnezhad

Saeed Aslani

Mansur Aliyu

Affiliations

Soon will be listed here.

Abstract

Several studies have previously assessed the association between interleukin (IL)-10 gene polymorphisms and the risk of asthma, leading to conflicting results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of the IL-10 gene rs1800896, rs1800871, and rs1800872 single-nucleotide polymorphisms (SNPs) and susceptibility to asthma. A systematic literature search performed until April 2020, and the pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated to determine the association strength. Thirty articles comprising 5678 asthmatic patients and 6079 controls met the inclusion criteria. No significant association was found between rs1800872 SNP and susceptibility to asthma across all genetic models in the overall and subgroup analyses. The rs1800871 SNP had only significant association with a decreased risk of asthma in Europeans (OR 0.66, CI 0.53-0.82, P < 0.001). However, rs1800896 SNP was significantly associated with a decreased risk of asthma by dominant (OR 0.67, CI 0.50-0.90, P < 0.001) and heterozygote (OR 0.66, CI 0.49-0.88, P < 0.001) models in the overall analysis. Subgroup analyses indicated significant association of rs1800896 SNP by dominant (OR 0.45, CI 0.28-0.72, P < 0.001) and heterozygote (OR 0.43, CI 0.26-0.70, P < 0.001) models in the African population. The IL-10 rs1800896 SNP confers protection against the risk of asthma, especially in Africans. Additionally, rs1800871 SNP has a protective role against asthma in Europeans.

Citing Articles

Network pharmacology integrated with molecular docking and molecular dynamics simulations to explore the mechanism of Shaoyao Gancao Tang in the treatment of asthma and irritable bowel syndrome.

Ren M, Ma J, Qu M Medicine (Baltimore). 2024; 103(50):e40929.

PMID: 39686413 PMC: 11651441. DOI: 10.1097/MD.0000000000040929.

A Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies.

Lio D, Di Lorenzo G, Brusca I, Scola L, Bellia C, La Piana S Genes (Basel). 2024; 15(8).

PMID: 39202464 PMC: 11353610. DOI: 10.3390/genes15081105.

Association between IL-10 (at position -592) and IL-4 (at position -589) genotype polymorphism with atopic and non-atopic asthma in children.

Razaghian A, Parvaneh N, Amirzargar A, Nirouei M, Gharagozlou M Am J Clin Exp Immunol. 2023; 12(5):98-106.

PMID: 38022870 PMC: 10658160.

Polymorphisms in Human , , and Genes Are Associated with an Increased Risk of Developing NSAID-Exacerbated Respiratory Disease.

Reigada-Rivera M, Lozano C, Rodilla E, Garcia-Sanchez A, Garcia-Solaesa V, Toledano F Genes (Basel). 2022; 13(4).

PMID: 35456412 PMC: 9031626. DOI: 10.3390/genes13040605.

References

Bahadori K, Doyle-Waters M, Marra C, Lynd L, Alasaly K, Swiston J . Economic burden of asthma: a systematic review. BMC Pulm Med. 2009; 9:24. PMC: 2698859. DOI: 10.1186/1471-2466-9-24. View

Barnes P . The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest. 2008; 118(11):3546-56. PMC: 2575722. DOI: 10.1172/JCI36130. View

Begg C, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088-101. View

Boulet L, Turcott H, Plante S, Chakir J . Airway function, inflammation and regulatory T cell function in subjects in asthma remission. Can Respir J. 2012; 19(1):19-25. PMC: 3299047. DOI: 10.1155/2012/347989. View

Cardaba B, Calzada D, Baos S, Aguerri M, Quiralte J, Lahoz C . Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and interleukin-10 in asthma associated with olive pollen sensitization. J Immunol Res. 2015; 2014:276345. PMC: 4352481. DOI: 10.1155/2014/276345. View

Chatterjee R, Batra J, Kumar A, Mabalirajan U, Nahid S, Niphadkar P . Interleukin-10 promoter polymorphisms and atopic asthma in North Indians. Clin Exp Allergy. 2005; 35(7):914-9. DOI: 10.1111/j.1365-2222.2005.02273.x. View

Daley D, Lemire M, Akhabir L, Chan-Yeung M, He J, McDonald T . Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet. 2009; 125(4):445-59. DOI: 10.1007/s00439-009-0643-8. View

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. PMC: 2127453. DOI: 10.1136/bmj.315.7109.629. View

10.

Fahy J . Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol. 2014; 15(1):57-65. PMC: 4390063. DOI: 10.1038/nri3786. View

11.

Hakimizadeh E, Arababadi M, Hassanshahi G, Nasiri Ahmadabadi B, Hakimi H, Rezaeian M . Association of -592 region of IL-10 polymorphisms with asthma in south-eastern Iranian patients. Clin Lab. 2012; 58(3-4):267-71. View

12.

Hakonarson H, Bjornsdottir U, Ostermann E, Arnason T, Adalsteinsdottir A, Halapi E . Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland. Am J Respir Crit Care Med. 2001; 164(11):2036-44. DOI: 10.1164/ajrccm.164.11.2101086. View

13.

Hang L, Hsia T, Chen W, Chen H, Tsai J, Tsai F . Interleukin-10 gene -627 allele variants, not interleukin-I beta gene and receptor antagonist gene polymorphisms, are associated with atopic bronchial asthma. J Clin Lab Anal. 2003; 17(5):168-73. PMC: 6808065. DOI: 10.1002/jcla.10088. View

14.

Hobbs K, Negri J, Klinnert M, Rosenwasser L, Borish L . Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med. 1998; 158(6):1958-62. DOI: 10.1164/ajrccm.158.6.9804011. View

15.

Hsia T, Chang W, Wang S, Shen T, Hsiao W, Liu C . The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults. In Vivo. 2015; 29(6):695-9. View

16.

Hussein Y, Shalaby S, Mohamed R, Hassan T . Association between genes encoding components of the IL-10/IL-0 receptor pathway and asthma in children. Ann Allergy Asthma Immunol. 2011; 106(6):474-80. DOI: 10.1016/j.anai.2011.02.021. View

17.

Hussein Y, Alzahrani S, Alharthi A, Ghonaim M, Alhazmi A, Eed E . Association of serum cytokines levels, interleukin 10 -1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia. Cell Immunol. 2014; 289(1-2):21-6. DOI: 10.1016/j.cellimm.2014.03.006. View

18.

Hyun M, Lee C, Kang M, Park B, Lee Y . Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis. PLoS One. 2013; 8(1):e53758. PMC: 3546046. DOI: 10.1371/journal.pone.0053758. View

19.

Jin H, Wang Y, Xu L . [Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013; 30(6):724-8. DOI: 10.3760/cma.j.issn.1003-9406.2013.06.020. View

20.

Karjalainen J, Hulkkonen J, Nieminen M, Huhtala H, Aromaa A, Klaukka T . Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma. Clin Exp Allergy. 2003; 33(1):78-83. DOI: 10.1046/j.1365-2222.2003.01577.x. View