Viruses in the Nucleus

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2021 Mar 23

PMID 33753405

Citations 10

Authors

Bojana Lucic

Ines J de Castro

Marina Lusic

Affiliations

Soon will be listed here.

Abstract

Viral infection is intrinsically linked to the capacity of the virus to generate progeny. Many DNA and some RNA viruses need to access the nuclear machinery and therefore transverse the nuclear envelope barrier through the nuclear pore complex. Viral genomes then become chromatinized either in their episomal form or upon integration into the host genome. Interactions with host DNA, transcription factors or nuclear bodies mediate their replication. Often interfering with nuclear functions, viruses use nuclear architecture to ensure persistent infections. Discovering these multiple modes of replication and persistence served in unraveling many important nuclear processes, such as nuclear trafficking, transcription, and splicing. Here, by using examples of DNA and RNA viral families, we portray the nucleus with the virus inside.

Citing Articles

Expanding Insights: Harnessing Expansion Microscopy for Super-Resolution Analysis of HIV-1-Cell Interactions.

Petrich A, Hwang G, La Rocca L, Hassan M, Anders-Osswein M, Sonntag-Buck V Viruses. 2024; 16(10).

PMID: 39459943 PMC: 11512423. DOI: 10.3390/v16101610.

Stepwise virus assembly in the cell nucleus revealed by spatiotemporal click chemistry of DNA replication.

Gomez-Gonzalez A, Burkhardt P, Bauer M, Suomalainen M, Mateos J, Loehr M Sci Adv. 2024; 10(43):eadq7483.

PMID: 39454009 PMC: 11506174. DOI: 10.1126/sciadv.adq7483.

An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy.

Qiu Y, Sajidah E, Kondo S, Narimatsu S, Sandira M, Higashiguchi Y Cells. 2024; 13(3.

PMID: 38334671 PMC: 10855070. DOI: 10.3390/cells13030279.

Appropriate reduction of importin-α gene expression enhances yellow dwarf disease resistance in common wheat.

Wang L, Zhang K, Wang Z, Yang J, Kang G, Liu Y Plant Biotechnol J. 2023; 22(3):572-586.

PMID: 37855813 PMC: 10893941. DOI: 10.1111/pbi.14204.

Contribution of carbohydrate-related metabolism in Herpesvirus infections.

Ma F, Fa C, Aj N, Aa S, Ia P, Lj C Curr Res Microb Sci. 2023; 4:100192.

PMID: 37273578 PMC: 10238445. DOI: 10.1016/j.crmicr.2023.100192.

References

Doucas V, Ishov A, ROMO A, Juguilon H, Weitzman M, Evans R . Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. Genes Dev. 1996; 10(2):196-207. DOI: 10.1101/gad.10.2.196. View

Blanco-Rodriguez G, Gazi A, Monel B, Frabetti S, Scoca V, Mueller F . Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes. J Virol. 2020; 94(11). PMC: 7269431. DOI: 10.1128/JVI.00135-20. View

Everett R, Chelbi-Alix M . PML and PML nuclear bodies: implications in antiviral defence. Biochimie. 2007; 89(6-7):819-30. DOI: 10.1016/j.biochi.2007.01.004. View

Campbell E, Hope T . HIV-1 capsid: the multifaceted key player in HIV-1 infection. Nat Rev Microbiol. 2015; 13(8):471-83. PMC: 4876022. DOI: 10.1038/nrmicro3503. View

Zhou H, Schmidt S, Jiang S, Willox B, Bernhardt K, Liang J . Epstein-Barr virus oncoprotein super-enhancers control B cell growth. Cell Host Microbe. 2015; 17(2):205-16. PMC: 4539236. DOI: 10.1016/j.chom.2014.12.013. View

Lusic M, Marini B, Ali H, Lucic B, Luzzati R, Giacca M . Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells. Cell Host Microbe. 2013; 13(6):665-77. DOI: 10.1016/j.chom.2013.05.006. View

Dias A, Dufu K, Lei H, Reed R . A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat Commun. 2010; 1:97. PMC: 3793428. DOI: 10.1038/ncomms1103. View

Mao Y, Zhang B, Spector D . Biogenesis and function of nuclear bodies. Trends Genet. 2011; 27(8):295-306. PMC: 3144265. DOI: 10.1016/j.tig.2011.05.006. View

Matreyek K, Yucel S, Li X, Engelman A . Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog. 2013; 9(10):e1003693. PMC: 3795039. DOI: 10.1371/journal.ppat.1003693. View

10.

Goujon C, Moncorge O, Bauby H, Doyle T, Ward C, Schaller T . Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature. 2013; 502(7472):559-62. PMC: 3808269. DOI: 10.1038/nature12542. View

11.

Yang Z, Yik J, Chen R, He N, Jang M, Ozato K . Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005; 19(4):535-45. DOI: 10.1016/j.molcel.2005.06.029. View

12.

Lucic B, Chen H, Kuzman M, Zorita E, Wegner J, Minneker V . Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration. Nat Commun. 2019; 10(1):4059. PMC: 6731298. DOI: 10.1038/s41467-019-12046-3. View

13.

LYCKE E, Hamark B, Johansson M, Krotochwil A, Lycke J, Svennerholm B . Herpes simplex virus infection of the human sensory neuron. An electron microscopy study. Arch Virol. 1988; 101(1-2):87-104. DOI: 10.1007/BF01314654. View

14.

Majumder K, Wang J, Boftsi M, Fuller M, Rede J, Joshi T . Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. Elife. 2018; 7. PMC: 6095691. DOI: 10.7554/eLife.37750. View

15.

Natarajan M, Schiralli Lester G, Lee C, Missra A, Wasserman G, Steffen M . Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013; 288(36):25995-26003. PMC: 3764804. DOI: 10.1074/jbc.M113.496489. View

16.

Heinz S, Texari L, Hayes M, Urbanowski M, Chang M, Givarkes N . Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018; 174(6):1522-1536.e22. PMC: 6130916. DOI: 10.1016/j.cell.2018.07.047. View

17.

Perkins K, Lusic M, Mitar I, Giacca M, Proudfoot N . Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals. Mol Cell. 2008; 29(1):56-68. PMC: 2225447. DOI: 10.1016/j.molcel.2007.11.030. View

18.

Ibarra A, Benner C, Tyagi S, Cool J, Hetzer M . Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 2016; 30(20):2253-2258. PMC: 5110992. DOI: 10.1101/gad.287417.116. View

19.

Timms R, Tchasovnikarova I, Antrobus R, Dougan G, Lehner P . ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex. Cell Rep. 2016; 17(3):653-659. PMC: 5081395. DOI: 10.1016/j.celrep.2016.09.050. View

20.

Horwitz G, Zhang K, McBrian M, Grunstein M, Kurdistani S, Berk A . Adenovirus small e1a alters global patterns of histone modification. Science. 2008; 321(5892):1084-5. PMC: 2756290. DOI: 10.1126/science.1155544. View