Using EEG and MEG to Characterize Extreme Delta Brush in a Patient with Anti-NMDA Receptor Encephalitis

Overview

Journal BMC Neurol

Publisher Biomed Central

Specialty Neurology

Date 2021 Mar 23

PMID 33752613

Citations 3

Authors

Ailiang Miao

Yongwei Shi

Jing Xiang

Xiaoshan Wang

Jianqing Ge

Qiqi Chen

Yuanwen Yu

Chuanyong Yu

Di Wu

Affiliations

Soon will be listed here.

Abstract

Background: Extreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear.

Case Presentation: A 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Electroencephalography (EEG) and magnetoencephalography (MEG) were used to analyze EDB in the patient. EDB on EEG could be disturbed by opening and closing the eyes, by occipital alpha rhythms and by sleep-wake cycles. The MEG results showed beta activity originating from bilateral superior parietal lobes. However, the delta wave originated from bilateral superior temporal gyri, the right middle temporal gyrus, the right inferior frontal gyrus, and the left inferior parietal lobe.

Conclusions: Delta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.

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Response: Extreme delta brush in anti-NMDAR encephalitis-Mimics and chameleons.

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