The Increasing Expression of GPX7 Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioma Patients

Overview

Journal Chin Neurosurg J

Publisher Biomed Central

Specialty Neurology

Date 2021 Mar 22

PMID 33750478

Citations 6

Authors

Jiawei Yao

Xin Chen

Zhendong Liu

Ruotian Zhang

Cheng Zhang

Quan Yang

Penglei Yao

Qiuyi Jiang

Jianing Wu

Shiguang Zhao

Affiliations

Soon will be listed here.

Abstract

Background: Glioma is the most common malignant brain tumor in adults. The standard treatment scheme of glioma is surgical resection combined alternative radio- and chemotherapy. However, the outcome of glioma patients was unsatisfied. Here, we aimed to explore the molecular and biological function characteristics of GPX7 in glioma.

Methods: The multidimensional data of glioma samples were downloaded from Chinese Glioma Genome Atlas (CGGA). RT-qPCR method was used to identify the expression status of GPX7. Kaplan-Meier curves and Cox regression analysis were used to explore the prognostic value of GPX7. Gene Set Enrichment Analysis (GSEA) was applied to investigate the GPX7-related functions in glioma.

Results: The results indicated that the expression of GPX7 in glioma was higher compared to that in normal brain tissue. Univariate and multivariate Cox regression analyses confirmed that the expression value of GPX7 was an independent prognostic factor in glioma. The GSEA analysis showed that GPX7 was significantly enriched in the cell cycle pathway, ECM pathway, focal adhesion pathway, and toll-like receptor pathway.

Conclusions: The GPX7 was recommended as an independent risk factor for patients diagnosed with glioma for the first time and GPX7 could be potentially used as the therapy target in future. Furthermore, we attempted to explore a potential biomarker for improving the diagnosis and prognosis of patients with glioma.

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