Anesthetics May Modulate Cancer Surgical Outcome: a Possible Role of MiRNAs Regulation

Overview

Journal BMC Anesthesiol

Publisher Biomed Central

Specialty Anesthesiology

Date 2021 Mar 22

PMID 33750303

Citations 12

Authors

Masashi Ishikawa

Masae Iwasaki

Atsuhiro Sakamoto

Daqing Ma

Affiliations

Soon will be listed here.

Abstract

Background: microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity.

Main Body: Anesthetics can affect cell biology through miRNA-mediated regulation of messenger RNA (mRNA). Indeed, sevoflurane was reported to upregulate miR-203 and suppresses breast cancer cell proliferation. Propofol reduces matrix metalloproteinase expression through its impact on miRNAs, leading to anti-cancer microenvironmental changes. Propofol also modifies miRNA expression profile in circulating extracellular vesicles with their subsequent anti-cancer effects via modulating cell-to-cell communication.

Conclusion: Inhalational and intravenous anesthetics can alter cancer cell biology through various cellular signaling pathways induced by miRNAs' modification. However, this area of research is insufficient and further study is needed to figure out optimal anesthesia regimens for cancer patients.

Citing Articles

Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells.

Hao X, Li Y, Gao H, Wang Z, Fang B Biomolecules. 2024; 14(9).

PMID: 39334933 PMC: 11430341. DOI: 10.3390/biom14091167.

The potential anti-tumor effect of anesthetics on cancer by regulating autophagy.

Wang T, Zhou Z, Jiang K, Wang Y, Li P, Wang S Front Pharmacol. 2024; 15:1293980.

PMID: 38482052 PMC: 10932962. DOI: 10.3389/fphar.2024.1293980.

Inhaled anesthesia associated with reduced mortality in patients with stage III breast cancer: A population-based study.

Kuo E, Kuo C, Lin C PLoS One. 2024; 19(3):e0289519.

PMID: 38427628 PMC: 10906904. DOI: 10.1371/journal.pone.0289519.

Potential 'anti-cancer' effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells.

Li C, Shi J, Wei S, Jia H Eur J Med Res. 2023; 28(1):517.

PMID: 37968758 PMC: 10647146. DOI: 10.1186/s40001-023-01511-x.

Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial.

Gluth L, Ochsenfarth C, Pham P, Wischermann J, Komanek T, Roghmann F Cells. 2023; 12(20).

PMID: 37887347 PMC: 10605791. DOI: 10.3390/cells12202503.

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