Association of Assisted Reproductive Technology Treatments with Imprinting Disorders

Overview

Journal Glob Med Genet

Publisher Thieme

Date 2021 Mar 22

PMID 33748817

Citations 5

Authors

T Kopca

Pinar Tulay

Affiliations

Soon will be listed here.

Abstract

Assisted reproductive technology (ART) is a broad field in infertility that encompasses different types of treatments. These revolutionary treatment methods aimed to aid infertile or subfertile couples. Treatment was expanded exponentially, as 1 to 3% of the births worldwide takes place with ART procedures. However, treatment is not flawless. Gametes and embryos are exposed to different chemicals and stress through treatment, which leads to disturbance in proper embryo development and results in prenatal and congenital anomalies. When compared with in-vivo development of gametes and preimplantation embryos in mice, in-vitro conditions during ART treatments have been suggested to disturb the gene expression levels, especially imprinted genes. Therefore, ART has been suggested to be associated with increased incidences of different imprinting disorders such as Beckwith-Wiedemann syndrome, Angelman syndrome, and Silver-Russell syndrome, as proved by different case reports and studies. This literature review aims to explain the association of imprinting disorders with this revolutionary treatment procedure.

Citing Articles

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Quantitative DNA Methylation Analysis and Epigenotype-Phenotype Correlations in Taiwanese Patients with Silver-Russell Syndrome.

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Impact of superovulation and in vitro fertilization on LINE-1 copy number and telomere length in C57BL/6 J mice blastocysts.

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Placental Dysfunction in Assisted Reproductive Pregnancies: Perinatal, Neonatal and Adult Life Outcomes.

Manna C, Lacconi V, Rizzo G, De Lorenzo A, Massimiani M Int J Mol Sci. 2022; 23(2).

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Epigenotype, Genotype, and Phenotype Analysis of Taiwanese Patients with Silver-Russell Syndrome.

Lin H, Lee C, Fran S, Tu R, Chang Y, Niu D J Pers Med. 2021; 11(11).

PMID: 34834549 PMC: 8624617. DOI: 10.3390/jpm11111197.

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