Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Mar 22

PMID 33748128

Citations 17

Authors

Ranjha Khan

Xiaohua Jiang

Uzma Hameed

Qinghua Shi

Affiliations

Soon will be listed here.

Abstract

It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession of lipids during oocyte development. Generally, lipids are mainly stored in the form of lipid droplets and are an important source of energy metabolism. Similarly, lipids are also essential signaling molecules involved in various biological cascades of oocyte maturation, growth and oocyte competence acquisition. To understand the role of lipids in controlling the oocyte development, we have comprehensively and concisely reviewed the literature and described the role of lipid metabolism in oocyte quality and maturation. Moreover, we have also presented a simplified model of fatty acid metabolism along with its implication on determining the oocyte quality and cryopreservation for fertilization.

Citing Articles

Effects of Different Levels of Antarctic Krill Oil on the Ovarian Development of .

Zheng X, Yang J, Liu X, Sun C, Zhou Q, Wang A Animals (Basel). 2024; 14(22).

PMID: 39595365 PMC: 11591225. DOI: 10.3390/ani14223313.

Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15.

Sigal E, Shavit M, Atzmon Y, Aslih N, Bilgory A, Estrada D Cells. 2024; 13(22).

PMID: 39594620 PMC: 11593194. DOI: 10.3390/cells13221872.

Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1-mediated uncoupling lipid catabolism during in vitro maturation.

Luo Y, Li J, Zheng L, Reyimjan Y, Ma Y, Huang S Cell Prolif. 2024; 57(11):e13687.

PMID: 38864666 PMC: 11533046. DOI: 10.1111/cpr.13687.

Unraveling the role of lipid droplets and perilipin 2 in bovine luteal cells.

Plewes M, Talbott H, Schott M, Wood J, Cupp A, Davis J FASEB J. 2024; 38(11):e23710.

PMID: 38822676 PMC: 11347014. DOI: 10.1096/fj.202400260RR.

Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and an Mouse Model Exposed to the Obesogen Chemical Tributyltin.

Pascuali N, Pu Y, Waye A, Pearl S, Martin D, Sutton A Environ Health Perspect. 2024; 132(4):47009.

PMID: 38630605 PMC: 11023052. DOI: 10.1289/EHP13955.

References

Enien W, el Sahwy S, Harris C, Seif M, Elstein M . Human chorionic gonadotrophin and steroid concentrations in follicular fluid: the relationship to oocyte maturity and fertilization rates in stimulated and natural in-vitro fertilization cycles. Hum Reprod. 1995; 10(11):2840-4. DOI: 10.1093/oxfordjournals.humrep.a135804. View

Zhao S, Tang X, Shao D, Dai H, Dai S . [Association study between a polymorphism of aldosterone synthetase gene and the pathogenesis of polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2003; 38(2):94-7. View

Pasquariello R, Ermisch A, Silva E, McCormick S, Logsdon D, Barfield J . Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†. Biol Reprod. 2018; 100(4):971-981. DOI: 10.1093/biolre/ioy248. View

Scalici E, Traver S, Mullet T, Molinari N, Ferrieres A, Brunet C . Circulating microRNAs in follicular fluid, powerful tools to explore in vitro fertilization process. Sci Rep. 2016; 6:24976. PMC: 4840336. DOI: 10.1038/srep24976. View

Ranneva S, Okotrub K, Amstislavsky S, Surovtsev N . Deuterated stearic acid uptake and accumulation in lipid droplets of cat oocytes. Arch Biochem Biophys. 2020; 692:108532. DOI: 10.1016/j.abb.2020.108532. View

Silveira J, Winger Q, Bouma G, Carnevale E . Effects of age on follicular fluid exosomal microRNAs and granulosa cell transforming growth factor-β signalling during follicle development in the mare. Reprod Fertil Dev. 2015; 27(6):897-905. DOI: 10.1071/RD14452. View

Lindheim L, Bashir M, Munzker J, Trummer C, Zachhuber V, Leber B . Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017; 12(1):e0168390. PMC: 5207627. DOI: 10.1371/journal.pone.0168390. View

Lin L, Du T, Huang J, Huang L, Yang D . Identification of differentially expressed microRNAs in the ovary of polycystic ovary syndrome with hyperandrogenism and insulin resistance. Chin Med J (Engl). 2015; 128(2):169-74. PMC: 4837833. DOI: 10.4103/0366-6999.149189. View

Leary C, Leese H, Sturmey R . Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod. 2014; 30(1):122-32. DOI: 10.1093/humrep/deu276. View

10.

Basuray R, Rawlins R, Radwanska E, Henig I, Sachdeva S, Tummon I . High progesterone/estradiol ratio in follicular fluid at oocyte aspiration for in vitro fertilization as a predictor of possible pregnancy. Fertil Steril. 1988; 49(6):1007-11. DOI: 10.1016/s0015-0282(16)59952-x. View

11.

Li S, Chu Q, Ma J, Sun Y, Tao T, Huang R . Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?. J Clin Endocrinol Metab. 2016; 102(3):810-821. PMC: 5477809. DOI: 10.1210/jc.2016-2692. View

12.

Wang F, Tian X, Zhang L, Tan D, Reiter R, Liu G . Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine. J Pineal Res. 2013; 55(3):267-74. DOI: 10.1111/jpi.12069. View

13.

Machtinger R, Laurent L, Baccarelli A . Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2015; 22(2):182-93. PMC: 4755440. DOI: 10.1093/humupd/dmv055. View

14.

Kelley S, Skarra D, Rivera A, Thackray V . The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One. 2016; 11(1):e0146509. PMC: 4701222. DOI: 10.1371/journal.pone.0146509. View

15.

Ferguson E, Leese H . A potential role for triglyceride as an energy source during bovine oocyte maturation and early embryo development. Mol Reprod Dev. 2006; 73(9):1195-201. DOI: 10.1002/mrd.20494. View

16.

Leroy J, Valckx S, Jordaens L, De Bie J, Desmet K, Van Hoeck V . Nutrition and maternal metabolic health in relation to oocyte and embryo quality: critical views on what we learned from the dairy cow model. Reprod Fertil Dev. 2015; 27(4):693-703. DOI: 10.1071/RD14363. View

17.

McEvoy T, Coull G, Broadbent P, HUTCHINSON J, Speake B . Fatty acid composition of lipids in immature cattle, pig and sheep oocytes with intact zona pellucida. J Reprod Fertil. 2000; 118(1):163-70. View

18.

Jin J, Lee S, Taweechaipaisankul A, Kim G, Lee B . Melatonin regulates lipid metabolism in porcine oocytes. J Pineal Res. 2017; 62(2). DOI: 10.1111/jpi.12388. View

19.

Cicek N, Eryilmaz O, Sarikaya E, Gulerman C, Genc Y . Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. J Assist Reprod Genet. 2012; 29(4):325-8. PMC: 3309992. DOI: 10.1007/s10815-012-9714-1. View

20.

Jungheim E, Macones G, Odem R, Patterson B, Lanzendorf S, Ratts V . Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril. 2011; 95(6):1970-4. PMC: 3080431. DOI: 10.1016/j.fertnstert.2011.01.154. View