Dissecting Sex-Related Cognition Between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Mar 22

PMID 33747345

Citations 5

Authors

Ghulam Md Ashraf

Mahmoud Ahmed Ebada

Mohd Suhail

Ashraf Ali

Md Sahab Uddin

Anwar L Bilgrami

Asma Perveen

Amjad Husain

Mohd Tarique

Abdul Hafeez

Athanasios Alexiou

Ausaf Ahmad

Rajnish Kumar

Naheed Banu

Agnieszka Najda

Amany A Sayed

Ghadeer M Albadrani

Mohamed M Abdel-Daim

Ilaria Peluso

George E Barreto

Affiliations

Soon will be listed here.

Abstract

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (A) pathogenesis, emphasizing how these drugs act in the male and female brains.

Citing Articles

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Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis.

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