The Aryl Hydrocarbon Receptor As a Modulator of Anti-viral Immunity

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Mar 22

PMID 33746961

Citations 22

Authors

Maria Florencia Torti

Federico Giovannoni

Francisco Javier Quintana

Cybele Carina Garcia

Affiliations

Soon will be listed here.

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial metabolites. The activation of AHR by these agonists drives its translocation into the nucleus where it controls the expression of a large number of target genes that include the AHR repressor (AHRR), detoxifying monooxygenases (CYP1A1 and CYP1B1), and cytokines. Recent advances reveal that AHR signaling modulates aspects of the intrinsic, innate and adaptive immune response to diverse microorganisms. This review will focus on the increasing evidence supporting a role for AHR as a modulator of the host response to viral infection.

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