Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy

Overview

Journal Mol Imaging

Publisher Sage Publications

Specialty Radiology

Date 2021 Mar 22

PMID 33746629

Citations 5

Authors

Ahmed Yassin

Khalid El-Salem

Abdel-Hameed Al-Mistarehi

Aiman Momani

Anas M Zein Alaabdin

Palak Shah

James Michael Mountz

Anto I Bagic

Affiliations

Soon will be listed here.

Abstract

Up to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resistant nonlesional extratemporal lobe epilepsy (ETLE) pose the biggest challenge in localizing the SOZ and require multiple noninvasive diagnostic investigations before planning the intracranial monitoring (ICM) or direct resection. Ictal Single Photon Emission Computed Tomography (i-SPECT) is a unique functional diagnostic tool that assesses the SOZ using the localized hyperperfusion that occurs early in the seizure. Subtraction ictal SPECT coregistered to MRI (SISCOM), statistical ictal SPECT coregistered to MRI (STATISCOM), and PET interictal subtracted ictal SPECT coregistered with MRI (PISCOM) are innovative SPECT methods for the determination of the SOZ. This article comprehensively reviews SPECT and sheds light on its vital role in the presurgical evaluation of the nonlesional extratemporal DRE.

Citing Articles

The diagnostic value of ictal SPECT-A retrospective, semiquantitative monocenter study.

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Suppressing interferences of EIT on synchronous recording EEG based on comb filter for seizure detection.

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Pavel D, Henderson T, DeBruin S Front Neurol. 2022; 12:749579.

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