Carotid Intima-media Thickness and Arterial Stiffness in Relation to Cerebral Small Vessel Disease in Neurologically Asymptomatic Individuals with Type 1 Diabetes

Overview

Journal Acta Diabetol

Specialty Endocrinology

Date 2021 Mar 20

PMID 33743083

Citations 8

Authors

Jussi Inkeri

Anniina Tynjala

Carol Forsblom

Ron Liebkind

Turgut Tatlisumak

Lena M Thorn

Per-Henrik Groop

Sara Shams

Jukka Putaala

Juha Martola

Daniel Gordin

Affiliations

Soon will be listed here.

Abstract

Aims: To determine if arterial functional and structural changes are associated with underlying cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes.

Methods: We enrolled 186 individuals (47.8% men; median age 40.0, IQR 33.0-45.0 years) with type 1 diabetes (median diabetes duration of 21.6, IQR 18.2-30.3 years), and 30 age- and sex-matched healthy controls, as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. All individuals underwent a biochemical work-up, brain magnetic resonance imaging (MRI), ultrasound of the common carotid arteries and arterial tonometry. Arterial structural and functional parameters were assessed by carotid intima-media thickness (CIMT), pulse wave velocity and augmentation index.

Results: Cerebral microbleeds (CMBs) were present in 23.7% and white matter hyperintensities (WMHs) in 16.7% of individuals with type 1 diabetes. Those with type 1 diabetes and CMBs had higher median (IQR) CIMT 583 (525 - 663) μm than those without 556 (502 - 607) μm, p = 0.016). Higher CIMT was associated with the presence of CMBs (p = 0.046) independent of age, eGFR, ApoB, systolic blood pressure, albuminuria, history of retinal photocoagulation and HbA. Arterial stiffness and CIMT were increased in individuals with type 1 diabetes and WMHs compared to those without; however, these results were not independent of cardiovascular risk factors.

Conclusions: Structural, but not functional, arterial changes are associated with underlying CMBs in asymptomatic individuals with type 1 diabetes.

Citing Articles

Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis.

Lever-Megina C, Cavero-Redondo I, Saz-Lara A, Moreno-Herraiz N, Rescalvo-Fernandez E, Otero-Luis I Hypertens Res. 2024; 48(1):314-326.

PMID: 39448810 DOI: 10.1038/s41440-024-01963-6.

Relationship between carotid intima-media thickness and white matter hyperintensities in non-stroke adults: a systematic review.

Humayra S, Yahya N, Ning C, Raffali M, Mir I, Mohamed A Front Neuroanat. 2024; 18:1394766.

PMID: 38903057 PMC: 11188707. DOI: 10.3389/fnana.2024.1394766.

Screening for Subclinical Atherosclerosis and the Prediction of Cardiovascular Events in People with Type 1 Diabetes.

Seres-Noriega T, Perea V, Amor A J Clin Med. 2024; 13(4).

PMID: 38398409 PMC: 10889212. DOI: 10.3390/jcm13041097.

No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes.

Inkeri J, Harjutsalo V, Martola J, Putaala J, Groop P, Gordin D Acta Diabetol. 2023; 61(4):441-449.

PMID: 38071692 PMC: 10963553. DOI: 10.1007/s00592-023-02211-y.

Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

Scheuermann B, Parr S, Schulze K, Kunkel O, Turpin V, Liang J J Am Heart Assoc. 2023; 12(23):e032616.

PMID: 37930079 PMC: 10727345. DOI: 10.1161/JAHA.123.032616.

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