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Case Fatality Risk of the SARS-CoV-2 Variant of Concern B.1.1.7 in England, 16 November to 5 February

Overview
Journal Euro Surveill
Specialty Infectious Diseases
Date 2021 Mar 19
PMID 33739254
Citations 115
Authors
Daniel J Grint
Kevin Wing
Elizabeth Williamson
Helen I McDonald
Krishnan Bhaskaran
David Evans
Stephen Jw Evans
Alex J Walker
George Hickman
Emily Nightingale
Anna Schultze
Christopher T Rentsch
Chris Bates
Jonathan Cockburn
Helen J Curtis
Caroline E Morton
Sebastian Bacon
Simon Davy
Angel Ys Wong
Amir Mehrkar
Laurie Tomlinson
Ian J Douglas
Rohini Mathur
Paula Blomquist
Brian Mackenna
Peter Ingelsby
Richard Croker
John Parry
Frank Hester
Sam Harper
Nicholas J DeVito
Will Hulme
John Tazare
Ben Goldacre
Liam Smeeth
Rosalind M Eggo
Affiliations
Soon will be listed here.
Abstract

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.

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