Anti-Infective, Anti-Inflammatory, and Immunomodulatory Properties of Breast Milk Factors for the Protection of Infants in the Pandemic From COVID-19

Overview

Journal Front Public Health

Specialty Public Health

Date 2021 Mar 19

PMID 33738273

Citations 17

Authors

Pasqua Anna Quitadamo

Laura Comegna

Pierpaolo Cristalli

Affiliations

Soon will be listed here.

Abstract

COVID-19 pandemic since the end of 2019 spreads worldwide, counting millions of victims. The viral invasion, systemic inflammation, and consequent organ failure are the gravest features of coronavirus disease 2019 (COVID-19), and they are associated with a high mortality rate. The aim of this study is to evaluate the role of breast milk in the COVID-19 pandemic, analyzing its antiviral, anti-inflammatory, and immunoregulatory effects due to its bioactive components, so numerous and important for the protection of infants. The study tried to demonstrate that all the components of human milk are capable of performing functions on all the pathogenic events recognized and described in COVID-19 disease. Those human milk factors are well-tolerated and practically free of side effects, so breast milk should become a research topic to discover therapies even in this epidemic. In the first part, the mechanisms of protection and defense of the breast milk elements will be delineated; in the second section, it will describe the human milk effects in viral infections and it will be hypothesized how the known mechanisms could act in COVID infection.

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References

Raoof N, Adamkin D, Radmacher P, Telang S . Comparison of lactoferrin activity in fresh and stored human milk. J Perinatol. 2015; 36(3):207-9. DOI: 10.1038/jp.2015.186. View

Rudloff S, Pohlentz G, Borsch C, Lentze M, Kunz C . Urinary excretion of in vivo ¹³C-labelled milk oligosaccharides in breastfed infants. Br J Nutr. 2011; 107(7):957-63. DOI: 10.1017/S0007114511004016. View

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Fanelli V, Vlachou A, Ghannadian S, Simonetti U, Slutsky A, Zhang H . Acute respiratory distress syndrome: new definition, current and future therapeutic options. J Thorac Dis. 2013; 5(3):326-34. PMC: 3698298. DOI: 10.3978/j.issn.2072-1439.2013.04.05. View

Ojo-Okunola A, Cacciatore S, Nicol M, du Toit E . The Determinants of the Human Milk Metabolome and Its Role in Infant Health. Metabolites. 2020; 10(2). PMC: 7074355. DOI: 10.3390/metabo10020077. View

Lebrao C, Cruz M, da Silva M, Dutra L, Cristiani C, Fonseca F . Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection. J Hum Lact. 2020; 36(4):609-613. PMC: 7783686. DOI: 10.1177/0890334420960433. View

Puccio G, Alliet P, Cajozzo C, Janssens E, Corsello G, Sprenger N . Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial. J Pediatr Gastroenterol Nutr. 2017; 64(4):624-631. PMC: 5378003. DOI: 10.1097/MPG.0000000000001520. View

Nair R, Warner B, Warner B . Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. Semin Perinatol. 2008; 32(2):107-13. DOI: 10.1053/j.semperi.2008.01.007. View

Kunz C, Rudloff S, Baier W, Klein N, Strobel S . Oligosaccharides in human milk: structural, functional, and metabolic aspects. Annu Rev Nutr. 2000; 20:699-722. DOI: 10.1146/annurev.nutr.20.1.699. View

10.

Bryan D, Hart P, Forsyth K, Gibson R . Immunomodulatory constituents of human milk change in response to infant bronchiolitis. Pediatr Allergy Immunol. 2007; 18(6):495-502. DOI: 10.1111/j.1399-3038.2007.00565.x. View

11.

Isaacs C . The antimicrobial function of milk lipids. Adv Nutr Res. 2002; 10:271-85. DOI: 10.1007/978-1-4615-0661-4_13. View

12.

Eiwegger T, Stahl B, Schmitt J, Boehm G, Gerstmayr M, Pichler J . Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res. 2004; 56(4):536-40. DOI: 10.1203/01.PDR.0000139411.35619.B4. View

13.

Decaro N, Mari V, Elia G, Addie D, Camero M, Lucente M . Recombinant canine coronaviruses in dogs, Europe. Emerg Infect Dis. 2009; 16(1):41-7. PMC: 2874359. DOI: 10.3201/eid1601.090726. View

14.

Turin C, Ochoa T . The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World. Curr Trop Med Rep. 2014; 1(2):97-105. PMC: 4036098. DOI: 10.1007/s40475-014-0015-x. View

15.

Dashraath P, Wong J, Lim M, Lim L, Li S, Biswas A . Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020; 222(6):521-531. PMC: 7270569. DOI: 10.1016/j.ajog.2020.03.021. View

16.

Abassi Z, Knaney Y, Karram T, Heyman S . The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?. Front Immunol. 2020; 11:1312. PMC: 7291598. DOI: 10.3389/fimmu.2020.01312. View

17.

Trinchieri G . Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003; 3(2):133-46. DOI: 10.1038/nri1001. View

18.

Ward P, Paz E, Conneely O . Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci. 2005; 62(22):2540-8. PMC: 11139086. DOI: 10.1007/s00018-005-5369-8. View

19.

Shoji H, Koletzko B . Oxidative stress and antioxidant protection in the perinatal period. Curr Opin Clin Nutr Metab Care. 2007; 10(3):324-8. DOI: 10.1097/MCO.0b013e3280a94f6d. View

20.

Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y . Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol. 2007; 120(4):916-23. DOI: 10.1016/j.jaci.2007.05.023. View