Etiology of Aggressive Periodontitis in Individuals of African Descent

Overview

Journal Jpn Dent Sci Rev

Publisher Elsevier

Specialty Dentistry

Date 2021 Mar 19

PMID 33737991

Citations 10

Authors

Akihiro Yoshida

Amal Bouziane

Samir Erraji

Leila Lakhdar

Meryem Rhissassi

Hideo Miyazaki

Toshihiro Ansai

Masanori Iwasaki

OumKeltoum Ennibi

Affiliations

Soon will be listed here.

Abstract

Aggressive periodontitis (AgP) is a form of periodontitis that affects adolescents and has a significantly higher prevalence in individuals of African descent. AgP typically shows familial aggregation, suggesting a genetic predisposition. Young age, good health status, rapid attachment loss, and familial aggregation are the primary features of this disease. AgP has been closely linked to specific bacterial strains of . strains isolated from patients with AgP produce leukotoxin (LtxA), which specifically affects polymorphonuclear leukocytes in primates, especially humans. High-throughput 16S rRNA gene sequencing and bioinformatics analyses revealed differences in the subgingival microbiota between patients with AgP and those with chronic periodontitis (ChP). The genera and show increased prevalences in AgP than in ChP. According to AgP susceptibility, several single nucleotide polymorphisms have been detected in different genes in individuals of African descent. Interleukin (IL)-1α and IL-1β genetic polymorphisms may be associated with the severity of both ChP and AgP. An elevated serum level of IL-17 produced by Th17 cells may be a characteristic of AgP. Analyses of the relationships among bacteria, host defenses, genetic predisposition, and numerous other factors are required to understand the progression of this disease.

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References

Pontes C, Gonzales J, Novaes Jr A, Junior M, Grisi M, Michel J . 'Interleukin-4 gene polymorphism and its relation to periodontal disease in a Brazilian population of African heritage'. J Dent. 2004; 32(3):241-6. DOI: 10.1016/j.jdent.2003.11.004. View

Califano J, Pace B, Gunsolley J, Schenkein H, Lally E, Tew J . Antibody reactive with Actinobacillus actinomycetemcomitans leukotoxin in early-onset periodontitis patients. Oral Microbiol Immunol. 1997; 12(1):20-6. DOI: 10.1111/j.1399-302x.1997.tb00362.x. View

Harris T, Wallace M, Huang H, Li H, Mohiuddeen A, Gong Y . Association of P2RX7 functional variants with localized aggressive periodontitis. J Periodontal Res. 2019; 55(1):32-40. PMC: 8018522. DOI: 10.1111/jre.12682. View

Zambon J . Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol. 1985; 12(1):1-20. DOI: 10.1111/j.1600-051x.1985.tb01348.x. View

Caton J, Armitage G, Berglundh T, Chapple I, Jepsen S, Kornman K . A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Clin Periodontol. 2018; 45 Suppl 20:S1-S8. DOI: 10.1111/jcpe.12935. View

Marazita M, Burmeister J, Gunsolley J, Koertge T, Lake K, Schenkein H . Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis. J Periodontol. 1994; 65(6):623-30. DOI: 10.1902/jop.1994.65.6.623. View

Cappelli D, Ebersole J, Kornman K . Early-onset periodontitis in Hispanic-American adolescents associated with A. actinomycetemcomitans. Community Dent Oral Epidemiol. 1994; 22(2):116-21. DOI: 10.1111/j.1600-0528.1994.tb01585.x. View

Roberts M, Atkinson J . Oral manifestations associated with leukocyte adhesion deficiency: a five-year case study. Pediatr Dent. 1990; 12(2):107-11. View

Boukortt K, Saidi-Ouahrani N, Boukerzaza B, Ouhaibi-Djellouli H, Hachmaoui K, Benaissa F . Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population. Arch Oral Biol. 2015; 60(10):1463-70. DOI: 10.1016/j.archoralbio.2015.06.018. View

10.

Almarza Novoa E, Kasbekar S, Thrasher A, Kohn D, Sevilla J, Nguyen T . Leukocyte adhesion deficiency-I: A comprehensive review of all published cases. J Allergy Clin Immunol Pract. 2018; 6(4):1418-1420.e10. DOI: 10.1016/j.jaip.2017.12.008. View

11.

Roman-Torres C, Aquino D, Cortelli S, Franco G, Dos Santos J, Corraini P . Prevalence and distribution of serotype-specific genotypes of Aggregatibacter actinomycetemcomitans in chronic periodontitis Brazilian subjects. Arch Oral Biol. 2010; 55(3):242-8. DOI: 10.1016/j.archoralbio.2010.01.008. View

12.

Haubek D, Poulsen K, Westergaard J, Dahlen G, Kilian M . Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin. J Clin Microbiol. 1996; 34(6):1576-8. PMC: 229068. DOI: 10.1128/jcm.34.6.1576-1578.1996. View

13.

Ennibi O, Benrachadi L, Bouziane A, Haubek D, Poulsen K . The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in localized and generalized forms of aggressive periodontitis. Acta Odontol Scand. 2012; 70(4):318-22. DOI: 10.3109/00016357.2011.642002. View

14.

Schenkein H, Koertge T, Brooks C, Sabatini R, Purkall D, Tew J . IL-17 in sera from patients with aggressive periodontitis. J Dent Res. 2010; 89(9):943-7. PMC: 3144093. DOI: 10.1177/0022034510369297. View

15.

TAICHMAN N, Shenker B, Tsai C, Glickman L, Baehni P, Stevens R . Cytopathic effects of Actinobacillus actinomycetemcomitans on monkey blood leukocytes. J Periodontal Res. 1984; 19(2):133-45. DOI: 10.1111/j.1600-0765.1984.tb00802.x. View

16.

Haraszthy V, Hariharan G, Tinoco E, Cortelli J, Lally E, Davis E . Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. J Periodontol. 2000; 71(6):912-22. DOI: 10.1902/jop.2000.71.6.912. View

17.

Fine D, Markowitz K, Fairlie K, Tischio-Bereski D, Ferrendiz J, Furgang D . A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis. J Clin Microbiol. 2013; 51(9):2850-61. PMC: 3754677. DOI: 10.1128/JCM.00729-13. View

18.

Loe H, Brown L . Early onset periodontitis in the United States of America. J Periodontol. 1991; 62(10):608-16. DOI: 10.1902/jop.1991.62.10.608. View

19.

Diehl S, Wang Y, Brooks C, Burmeister J, Califano J, Wang S . Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol. 1999; 70(4):418-30. DOI: 10.1902/jop.1999.70.4.418. View

20.

Nibali L, Donos N, Brett P, Parkar M, Ellinas T, Llorente M . A familial analysis of aggressive periodontitis - clinical and genetic findings. J Periodontal Res. 2008; 43(6):627-34. DOI: 10.1111/j.1600-0765.2007.01039.x. View