Poxvirus CGAMP Nucleases: Clues and Mysteries from a Stolen Gene

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2021 Mar 18

PMID 33735254

Citations 4

Authors

Carlos Maluquer de Motes

Affiliations

Soon will be listed here.

Citing Articles

Birth of protein folds and functions in the virome.

Nomburg J, Doherty E, Price N, Bellieny-Rabelo D, Zhu Y, Doudna J Nature. 2024; 633(8030):710-717.

PMID: 39187718 PMC: 11410667. DOI: 10.1038/s41586-024-07809-y.

Evolutionary immunology to explore original antiviral strategies.

Imler J, Cai H, Meignin C, Martins N Philos Trans R Soc Lond B Biol Sci. 2024; 379(1901):20230068.

PMID: 38497262 PMC: 10945398. DOI: 10.1098/rstb.2023.0068.

Lumpy Skin Disease Virus Genome Sequence Analysis: Putative Spatio-Temporal Epidemiology, Single Gene versus Whole Genome Phylogeny and Genomic Evolution.

Breman F, Haegeman A, Kresic N, Philips W, de Regge N Viruses. 2023; 15(7).

PMID: 37515159 PMC: 10385495. DOI: 10.3390/v15071471.

Zebrafish-based platform for emerging bio-contaminants and virus inactivation research.

Patel P, Nandi A, Verma S, Kaushik N, Suar M, Choi E Sci Total Environ. 2023; 872:162197.

PMID: 36781138 PMC: 9922160. DOI: 10.1016/j.scitotenv.2023.162197.

References

Muhlemann B, Vinner L, Margaryan A, Wilhelmson H, de la Fuente Castro C, Allentoft M . Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age. Science. 2020; 369(6502). DOI: 10.1126/science.aaw8977. View

Lelli D, Lavazza A, Prosperi A, Sozzi E, Faccin F, Baioni L . Hypsugopoxvirus: A Novel Poxvirus Isolated from in Italy. Viruses. 2019; 11(6). PMC: 6631891. DOI: 10.3390/v11060568. View

Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I . cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013; 498(7454):380-4. PMC: 4143541. DOI: 10.1038/nature12306. View

Smith G, Benfield C, Maluquer de Motes C, Mazzon M, Ember S, Ferguson B . Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. J Gen Virol. 2013; 94(Pt 11):2367-2392. DOI: 10.1099/vir.0.055921-0. View

Xie J, Li Y, Shen X, Goh G, Zhu Y, Cui J . Dampened STING-Dependent Interferon Activation in Bats. Cell Host Microbe. 2018; 23(3):297-301.e4. PMC: 7104992. DOI: 10.1016/j.chom.2018.01.006. View

Hernaez B, Alonso G, Georgana I, El-Jesr M, Martin R, Shair K . Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection. Sci Adv. 2020; 6(38). PMC: 7500930. DOI: 10.1126/sciadv.abb4565. View

Ablasser A, Chen Z . cGAS in action: Expanding roles in immunity and inflammation. Science. 2019; 363(6431). DOI: 10.1126/science.aat8657. View

Barnowski C, Ciupka G, Tao R, Jin L, Busch D, Tao S . Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions. Front Immunol. 2020; 11:1458. PMC: 7381110. DOI: 10.3389/fimmu.2020.01458. View

Agueda-Pinto A, de Matos A, Abrantes M, Kraberger S, Risalde M, Gortazar C . Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (). Viruses. 2019; 11(6). PMC: 6631704. DOI: 10.3390/v11060530. View

10.

Gubser C, Goodbody R, Ecker A, Brady G, ONeill L, Jacobs N . Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence. J Gen Virol. 2007; 88(Pt 6):1667-1676. PMC: 2885618. DOI: 10.1099/vir.0.82748-0. View

11.

Eaglesham J, McCarty K, Kranzusch P . Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife. 2020; 9. PMC: 7688311. DOI: 10.7554/eLife.59753. View

12.

Georgana I, Sumner R, Towers G, Maluquer de Motes C . Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation. J Virol. 2018; 92(10). PMC: 5923072. DOI: 10.1128/JVI.02145-17. View

13.

Banerjee A, Baker M, Kulcsar K, Misra V, Plowright R, Mossman K . Novel Insights Into Immune Systems of Bats. Front Immunol. 2020; 11:26. PMC: 7025585. DOI: 10.3389/fimmu.2020.00026. View

14.

Emerson G, Nordhausen R, Garner M, Huckabee J, Johnson S, Wohrle R . Novel poxvirus in big brown bats, northwestern United States. Emerg Infect Dis. 2013; 19(6):1002-4. PMC: 3713833. DOI: 10.3201/eid1906.121713. View

15.

Hertzog J, Rehwinkel J . Regulation and inhibition of the DNA sensor cGAS. EMBO Rep. 2020; 21(12):e51345. PMC: 7726805. DOI: 10.15252/embr.202051345. View

16.

Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I . Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS Pathog. 2014; 10(4):e1003989. PMC: 3990710. DOI: 10.1371/journal.ppat.1003989. View

17.

Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G . Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun. 2018; 9(1):4424. PMC: 6200793. DOI: 10.1038/s41467-018-06922-7. View

18.

Eaglesham J, Pan Y, Kupper T, Kranzusch P . Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019; 566(7743):259-263. PMC: 6640140. DOI: 10.1038/s41586-019-0928-6. View

19.

ODea M, Tu S, Pang S, De Ridder T, Jackson B, Upton C . Genomic characterization of a novel poxvirus from a flying fox: evidence for a new genus?. J Gen Virol. 2016; 97(9):2363-2375. DOI: 10.1099/jgv.0.000538. View

20.

Sun L, Wu J, Du F, Chen X, Chen Z . Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2012; 339(6121):786-91. PMC: 3863629. DOI: 10.1126/science.1232458. View