Disparate Outcomes in Nonsmall Cell Lung Cancer by Immigration Status

Overview

Journal Cancer Med

Specialty Oncology

Date 2021 Mar 18

PMID 33734614

Citations 2

Authors

Brittney Chau

Philip Hg Ituarte

Ashwin Shinde

Richard Li

Jessica Vazquez

Scott Glaser

Erminia Massarelli

Ravi Salgia

Loretta Erhunmwunsee

Kimlin Ashing

Arya Amini

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this study was to evaluate overall survival (OS) outcomes by race, stratified by country of origin in patients diagnosed with NSCLC in California.

Methods: We performed a retrospective analysis of nonsmall cell lung cancer (NSCLC) patients diagnosed between 2000 and 2012. Race/ethnicity was defined as White (W), Black (B), Hispanic (H), and Asian (A) and stratified by country of origin (US vs. non-US [NUS]) creating the following patient cohorts: W-US, W-NUS, B-US, B-NUS, H-US, H-NUS, A-US, and A-NUS. Three multivariate models were created: model 1 adjusted for age, gender, stage, year of diagnosis and histology; model 2 included model 1 plus treatment modalities; and model 3 included model 2 with the addition of socioeconomic status, marital status, and insurance.

Results: A total of 68,232 patients were included. Median OS from highest to lowest were: A-NUS (15 months), W-NUS (14 months), A-US (13 months), B-NUS (13 months), H-US (11 months), W-US (11 months), H-NUS (10 months), and B-US (10 months) (p < 0.001). In model 1, B-US had worse OS, whereas A-US, W-NUS, B-NUS, H-NUS, and A-NUS had better OS when compared to W-US. In model 2 after adjusting for receipt of treatment, there was no difference in OS for B-US when compared to W-US. After adjusting for all variables (model 3), all race/ethnicity profiles had better OS when compared to W-US; B-NUS patients had similar OS to W-US.

Conclusion: Foreign-born patients with NSCLC have decreased risk of mortality when compared to native-born patients in California after accounting for treatments received and socioeconomic differences.

Citing Articles

A nationwide analysis of disparities in guideline-concordant care in American Indians and Alaska Natives with stage I non-small cell lung cancer.

Schoephoerster J, Praska C, White M, Salami A, Marmor S, Andrade R J Thorac Dis. 2023; 15(11):5891-5900.

PMID: 38090326 PMC: 10713313. DOI: 10.21037/jtd-23-801.

Hypothesized Explanations for the Observed Lung Cancer Survival Benefit Among Hispanics/Latinos in the United States.

Miao E, Klugman M, Rohan T, Hosgood 3rd H J Racial Ethn Health Disparities. 2022; 10(3):1339-1348.

PMID: 35524005 DOI: 10.1007/s40615-022-01319-1.

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