Accelerating ESD-induced Gastric Ulcer Healing Using a PH-responsive Polyurethane/small Intestinal Submucosa Hydrogel Delivered by Endoscopic Catheter

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2021 Mar 18

PMID 33732501

Citations 6

Authors

Long-Mei Zhao

Mei Gong

Rui Wang

Qi-Juan Yuan

Yi Zhang

Jin-Kui Pi

Xiu-He Lv

Yan Xie

Hui-Qi Xie

Affiliations

Soon will be listed here.

Abstract

Endoscopic submucosal dissection (ESD) is the standard treatment for early-stage gastric cancer, but the large post-operative ulcers caused by ESD often lead to serious side effects. Post-ESD mucosal repair materials provide a new option for the treatment of post-ESD ulcers. In this study, we developed a polyurethane/small intestinal submucosa (PU/SIS) hydrogel and investigated its efficacy for accelerating ESD-induced ulcer healing in a canine model. PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions . Besides, PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions, thus ensuring the retention time of PU/SIS gels . In a canine model, PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites. PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation. Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.

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